Coronary artery diseaseThirty-Month Outcome After Fractional Flow Reserve–Guided Versus Conventional Multivessel Percutaneous Coronary Intervention
Section snippets
Study patients and lesions
From October 2000 to August 2002, 137 consecutive patients (312 vessels) were prospectively assigned to either FFR-PCI (57 patients, 128 vessels) or conventional PCI (80 patients, 184 vessels). The choice between FFR-guided PCI and conventional PCI was left to the discretion of the operators and was primarily dictated by patient preference and the prevailing number of patients enrolled in each group to even out the number of patients. Patients were included in this study if they had stable
Clinical characteristics
The clinical features of the 2 groups are listed in Table 1. FFR and PCI were successfully performed in all patients. The 2 groups were matched with respect to clinical characteristics, including age, gender, and major cardiovascular risk factors (Table 1).
Procedural and angiographic characteristics
The procedural and angiographic characteristics of the 2 groups are listed in Table 2. Angiographic and procedural success was achieved in 98.3% versus 97.5% and 87% versus 76% in the FFR-PCI and conventional PCI groups, respectively (p = NS;
Discussion
The results of this study have demonstrated that among patients with MVD, a decision-making strategy based on a FFR of <0.75 to perform PCI is associated with a 30-month event-free survival estimate of 89%, significantly higher than that resulting from a strategy based on the visual estimation of the stenosis. Furthermore, using a strategy such as FFR-guided PCI avoids unnecessary resource utilization and thereby significantly reduces the cost of the procedure. In line with this, our results
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