Coronary artery diseaseImpact of Clopidogrel on Suppression of Circulating Levels of Soluble CD40 Ligand in Patients With Unstable Angina Undergoing Coronary Stenting
References (20)
- et al.
An analysis of platelet activation and aggregation produced by three classes of contrast media
J Vasc Interv Radiol
(1995) - et al.
Neutrophil and platelet activation at balloon-injured coronary artery plaque in patients undergoing angioplasty
J Am Coll Cardiol
(1996) - et al.
Effects of tirofiban and statins on high-sensitivity C-reactive protein, interleukin-6, and soluble CD40 ligand following percutaneous coronary interventions in patients with stable coronary artery disease
Am J Cardiol
(2005) - et al.
Coronary angioplasty induces a systemic inflammatory response
Am J Cardiol
(1997) - et al.
Association between C-reactive protein levels and subsequent cardiac events among patients with stable angina treated with coronary artery stenting
Am J Med
(2003) - et al.
Coronary angioplasty results in leukocyte and platelet activation with adhesion molecule expression
J Am Coll Cardiol
(1997) - et al.
Preprocedural level of soluble CD40L is predictive of enhanced inflammatory response and restenosis after coronary angioplasty
Circulation
(2003) - et al.
Platelet reactivity characterized prospectively a determinant of outcome 90 days after percutaneous coronary intervention
Circulation
(2001) - et al.
CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
Nature
(1998) - et al.
Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophagesimplication CD40-CD40 ligand signaling in atherosclerosis
Proc Natl Acad Sci USA
(1997)
Cited by (28)
Platelet CD40 ligand and bleeding during P2Y12 inhibitor treatment in acute coronary syndrome
2019, Research and Practice in Thrombosis and HaemostasisPrasugrel as opposed to clopidogrel improves endothelial nitric oxide bioavailability and reduces platelet-leukocyte interaction in patients with unstable angina pectoris: A randomized controlled trial
2017, International Journal of CardiologyCitation Excerpt :Increased blood levels of sCD40L are found in unstable angina patients [39] and associated with higher cardiovascular risk in ACS [40]. Various studies provide evidence that platelet inhibition with clopidogrel reduces sCD40L [9,26,41,42] and RANTES levels [9]. The observations in our study are partly in line with previous data, since we also observed a decrease in sCD40L and RANTES in both treatment arms, although it did only reach statistical significance in the prasugrel group suggesting a relevant reduction in platelet-mediated inflammation.
The CD40/CD40L system: A new therapeutic target for disease
2013, Immunology LettersCitation Excerpt :Clopidogrel mitigates platelet aggregation by inhibiting the ADP receptor, and it has been widely used in acute coronary syndrome and in percutaneous coronary intervention patients. Presumably, as a consequence of inhibiting the ADP receptor, clopidogrel also decreases plasma sCD40L levels induced by activated platelets [30], thereby delaying the development of AS. Unexpectedly, it has been reported that CD40L expression on platelets increased rather decreased in CAD patients who have had pharmacotherapy with clopidogrel (75 mg/d) and aspirin (325 mg/d) for one year [31].
The CD40/CD40 Ligand System. Linking Inflammation With Atherothrombosis
2009, Journal of the American College of CardiologyCitation Excerpt :As activated platelets are the main source of circulating sCD40L, antiplatelet agents were among the first drugs studied for their CD40L-lowering properties. Clopidogrel, which acts via adenosine diphosphate receptor inhibition, completely inhibits sCD40L release from adenosine diphosphate-stimulated platelets; patients under clopidogrel treatment exhibit reduced CD40L platelet expression and circulating sCD40L levels (54). Moreover, it was also found that both short- and long-term treatment with clopidogrel significantly reduces sCD40L levels in patients with stable CAD (55), although a recent study demonstrated enhanced expression of CD40L on platelets surface after 1 year of treatment with clopidogrel 75 mg/day plus aspirin 325 mg/day in patients with CAD (56).
Association of CD40 SNPs with Moyamoya in a Chinese children population
2019, British Journal of NeurosurgeryMen with lower HDL cholesterol levels have significant increment of soluble CD40 ligand and high-sensitivity CRP levels following the cessation of long-term clopidogrel therapy
2015, Journal of Atherosclerosis and Thrombosis