Coronary artery diseaseUsefulness of Baseline Plasma Myeloperoxidase Levels as an Independent Predictor of Myocardial Infarction at Two Years in Patients Presenting With Acute Coronary Syndrome
Section snippets
Methods
This study was conducted at a Veterans Administration Medical Center and was approved by the local institutional review board. Written informed consent was obtained from all patients. Between January 1999 and October 2002, 193 men who underwent diagnostic coronary angiography for evaluation of ACS were enrolled in the study. Patients with active gastrointestinal bleeding were excluded from the study. Three groups of patients were categorized by type of ACS4: (1) the group with ST-elevation
Results
In total, 193 men were enrolled in the study. MPO values were available for 182 of these patients. Baseline clinical and laboratory characteristics of the study population stratified by the median MPO value for the cohort are listed in Table 1. The breakdown of the patient population based on the primary indication for coronary angiography was as follows: ST-segment elevation MI in 23 patients (12%), non–ST-segment elevation MI in 84 patients (43%), and troponin-negative unstable angina in 86
Discussion
In a broad cohort of patients with ACS, we found a strong and statistically significant independent association between increased baseline levels of MPO and subsequent development of MI in the ensuing 24 months. Although there are compelling data relating increased baseline MPO levels to poor short-term prognosis in ACS, similar data for long-term outcomes are lacking. This is in contrast to other inflammatory biomarkers, such as hs-CRP, which have been shown to be predictive of short- and
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