Coronary artery diseaseUsefulness of 64-Slice Multidetector Computed Tomography for Detecting Drug Eluting In-Stent Restenosis
Section snippets
Methods
From November 2005 to August 2006, 57 consecutive patients with previous stent implantation who were scheduled for ICA were included in the study to compare multidetector computed tomography (MDCT) with the gold standard, ICA. We excluded patients with the following characteristics: previous allergic reaction to iodinated contrast agent, impaired renal function (serum creatinine >1.6 mg/dl), contraindication to β blockers (high-degree heart block, poor left ventricular function, asthma, or
Results
Two of the 45 patients selected for the study had technically inadequate scans: the first for scan failure, and the second for arrhythmia during the scan. Moreover, 1 patient was excluded from the study because of an allergic reaction to iodinated contrast agent after MDCT and another because of refused participation. The remaining 41 patients constituted the study population. The baseline clinical and angiographic characteristics of these patients are listed in Table 1, and the stent (n = 87)
Discussion
Although the reported accuracy for 16- and 64-slice MDCT in the assessment of stenoses in nonstented coronary arteries is high, the visualization of the lumen within coronary artery stents is more challenging, because the stents produce artifacts by increasing the strut thickness (partial volume artifacts) and thereby artificially reducing the intrastent lumen. Only a small number of studies, performed using 16-slice MDCT, have evaluated the value of MDCT to detect ISR.1, 2, 3, 4, 5 In these
Acknowledgment
We would like to acknowledge the expert assistance of Antonella Pastorini, anesthesiologist; Daniela Roberto, Lapo Caratelli, and Sergio Armeli, radiologist technicians; and Paola Baldini and Fabio Torrini, technicians, in the performance of this study.
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