Heart failurePrognostic Value of Pulse-Wave Tissue Doppler Parameters in Patients With Systolic Heart Failure
Section snippets
Methods
Patients with signs and symptoms of acute decompensated heart failure (HF) who were admitted to the Department of Cardiology at Sodersjukhuset, Stockholm, Sweden, from September 1999 to April 2004 were screened for this study. Patients were asked to participate if LV ejection fraction was ≤40%. Exclusion criteria were LV ejection fraction >40%, severe valvular disease, and age >85 years. Eventually, 156 patients were included in the study. Before discharge and in a reasonably stable clinical
Results
Table 1 lists baseline clinical characteristics of the study population. Table 2 lists conventional and TDI parameters obtained at the examination that initiated the study. Mean LV ejection fraction was severely depressed at 25%. All surviving patients were followed up for ≥24 months. During follow-up, 27 patients (17%) died of a cardiovascular cause and thus reached the study end point. Table 3 lists the output of univariate Cox regression analysis. Factors that affected the outcome of
Discussion
This study was the first to investigate the prognostic importance of TDI parameters in a mixed population with HF and severe LV systolic dysfunction that included patients with atrial fibrillation. Our study showed that the E/e′ ratio measured in the acute stage of hospitalization was the most powerful predictor of cardiovascular death in this type of population This parameter was superior to other echocardiographic and clinical variables, such as LV ejection fraction, LV end-diastolic
Acknowledgment
We thank Eva Andersson and Johan Wardell for valuable technical help.
References (12)
- et al.
Mitral annular descent velocity by tissue Doppler echocardiography as an index of global left ventricular function
Am J Cardiol
(1996) - et al.
Assessment of mitral annulus velocity by Doppler tissue imaging in the evaluation of left ventricular diastolic function
J Am Coll Cardiol
(1997) - et al.
Clinical application of pulsed Doppler tissue imaging for assessing abnormal left ventricular relaxation
Am J Cardiol
(1997) - et al.
Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures
J Am Coll Cardiol
(1997) - et al.
Peak early diastolic mitral annulus velocity by tissue Doppler imaging adds independent and incremental prognostic value
J Am Coll Cardiol
(2003) - et al.
Incremental predictive power of B-type natriuretic peptide and tissue Doppler echocardiography in the prognosis of patients with congestive heart failure
J Am Coll Cardiol
(2005)
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This work was supported by a grant from Stockholms läns landsting (ALF medicine), Stockholm, Sweden.