Preventive cardiologyArterial Age as a Function of Coronary Artery Calcium (from the Multi-Ethnic Study of Atherosclerosis [MESA])
Section snippets
Methods
MESA is a prospective cohort study of the prevalence, risk factors, and progression of subclinical cardiovascular disease in a multiethnic community-based cohort. A detailed description of the study design and methods has been published previously.8 Briefly, 6,814 participants aged 45 to 84 years who identified themselves as white, African American, Hispanic, or Chinese were recruited from 6 communities in the United States from 2000 to 2002. All participants were free of clinically apparent
Results
The MESA cohort is composed of 53% women, with 39% of the cohort Caucasian, 12% Chinese American, 28% African American, and 22% Hispanic American. The average age is 62 years, with a range of 45 to 84 years. Over an average of 4 years of follow-up, 189 incident CHD events were observed in MESA, including 108 hard CHD events (myocardial infarction and CHD death). Estimated arterial age is given by , with the approximate standard error (SE) given by
Discussion
Most previous studies have estimated arterial age as the age for which the expected CAC is equal to the observed CAC. Shaw et al3 regressed observed age on observed CAC and then estimated “biologic age” by the fitted values from this model. A feature of this model is that anyone with zero CAC will be assigned the model intercept, which in our data was just slightly younger than the average age of the cohort. Thus, anyone younger than the average age of the cohort with a zero score will have a
Acknowledgment
We thank the other investigators, the staff members, and the participants of the MESA study for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org.
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This research was supported by Contracts N01-HC-95159 through N01-HC-95165 and N01-HC-95169 from the National Heart, Lung, and Blood Institute, Bethesda, Maryland.