Arrhythmias and conduction disturbanceCardiac Arrhythmias in Obstructive Sleep Apnea (from the Akershus Sleep Apnea Project)
Section snippets
Methods
This is a substudy of the Akershus Sleep Apnea Project (ASAP). The recruitment protocol and main inclusion and exclusion criteria have been previously reported.6 In brief, the Berlin Questionnaire was mailed to 30,000 randomly selected patients 30 to 65 years of age (Figure 1). The Berlin Questionnaire includes questions on daytime sleepiness, snoring, and obesity/hypertension and is used to stratify patients for risk of OSA. Of the 16,302 responders, 1,772 subjects were further categorized in
Results
In total, 535 participants were included in the clinical phase of the study (Figure 1). Of these, 49 subjects were excluded because of unsatisfactory polysomnographic recordings or technical problems with Holter registration. Baseline characteristics of subjects with and without OSA are presented in Table 2. In general, subjects diagnosed with OSA were older, more obese, and more likely to be men compared to subjects without OSA. Subjects with OSA also exhibited a higher prevalence of
Discussion
The principal findings of this study are that OSA of mainly mild and moderate severity is associated with an increased prevalence of ventricular arrhythmias in middle-aged subjects and that high AHI is independently associated with frequent ventricular premature complexes in analyses that adjusted for relevant covariates.
Our results are in line with results previously reported for patients with severe OSA. The first reports of an association between OSA and cardiac arrhythmias were in patients
Acknowledgment
We thank the staff at Akershus University Hospital, Department Stensby, and the other researchers of the ASAP who contributed to the project.
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This study was supported by Grant 2004219 the South-Eastern Norway Regional Health Authority and the University of Oslo, Oslo, Norway.