Original articleCardiovascularRisk Factors Associated With Reoperation and Mortality in 252 Patients After Aortic Valve Replacement for Congenitally Bicuspid Aortic Valve Disease
Section snippets
Patients
From February 1971 through March 2002, all patients who underwent AVR surgery for congenital BAV were identified through our division’s computerized database for inclusion in the study if they did not undergo concomitant AA repair or replacement or other valve replacement surgery. This study was approved by the Institutional Review Board at Cedars-Sinai Medical Center with a waiver to obtain consent based on the retrospective study nature and removal of identification of patient data. All
Results
A total of 252 patients with BAV underwent AVR without concomitant replacement of AA. The mean follow-up was 8.9 ± 6.3 years (range, 0–31.0 years). Of the 252 patients, 50.4% had aortic stenosis, 12.4% had aortic regurgitation, and 37.2% mixed lesions.
All patients underwent AVR; no aortic valve repair was done. A tissue valve was used in 35.3% of patients, a mechanical valve in 54.4% of patients, and a pulmonary allograft was placed in 10.3% of patients. Concomitant coronary artery bypass graft
Comment
Bicuspid aortic valve disease is a common congenital cardiac disorder affecting 1% to 2% of the general population with an autosomal dominant inheritance pattern [1, 2, 24]. Large autopsy studies described aortic stenosis as the predominant lesion in a population with BAV with a lower incidence (10% to 15%) of aortic insufficiency and mixed lesions [4]. In the present study of 252 patients with BAV, we found that half of the patients had pure aortic stenosis and 37% had mixed lesions. The age
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