Original articleAdult cardiacPathogenesis of Acute Aortic Dissection: A Finite Element Stress Analysis
Section snippets
Material and Methods
This study was approved by the Institutional Review Board.
Patient Characteristics
The 47 study patients were a mean age of 56.2 ± 15.6 years, and 24 (51.1%) had hypertension. Maximum aortic diameter of the study population was 3.5 ± 0.6 cm at the aortic root, 3.0 ± 0.5 cm at the STJ, 3.3 ± 0.5 cm in the ascending aorta, 2.5 ± 0.4 in the aortic arch, and 2.4 ± 0.3 in the descending thoracic aorta. The aortic arches were type I in 29 patients and type II in 18. There was no difference between the two groups (Table 1).
Comparison of Wall Stress Throughout the Thoracic Aorta
Comparison of peak wall stress above the STJ (0.43 ± 0.09
Comment
The current research uses FEA to demonstrate increased wall stress in the human thoracic aorta above the STJ and distal to the LSA, where the intimal tears that result in type A and type B aortic dissections typically occur. The wall stress above the STJ was greater than that distal to the LSA, consistent with type A dissections being more common than type B dissections [1, 2, 3, 4]. Older patients were more likely to have a type II arch, as previous studies have shown [15]. However, aortic
References (35)
- et al.
Epidemiology and clinicopathology of aortic dissection
Chest
(2000) - et al.
Acute aortic dissection: population-based incidence compared with degenerative aortic aneurysm rupture
Mayo Clin Proc
(2004) - et al.
Fluid-structure interaction analysis of turbulent pulsatile flow within a layered aortic wall as related to aortic dissection
J Biomech
(2009) - et al.
Prediction of rupture risk in abdominal aortic aneurysm during observation: wall stress versus diameter
J Vasc Surg
(2003) - et al.
Characterizing the young patient with aortic dissection: results from the International Registry of Acute Aortic Dissection (IRAD)
J Am Coll Cardiol
(2004) Heritable disorders predisposing to aortic dissection
Semin Thorac Cardiovasc Surg
(2005)- et al.
Impact of calcification and intraluminal thrombus on the computed wall stresses of abdominal aortic aneurysm
J Vasc Surg
(2008) - et al.
Circumferential and longitudinal cyclic strain of the human thoracic aorta: age-related changes
J Vasc Surg
(2009) - et al.
Patient-specific AAA wall stress analysis: 99-percentile versus peak stress
Eur J Vasc Endovasc Surg
(2008) - et al.
Mechanical wall stress in abdominal aortic aneurysm: influence of diameter and asymmetry
J Vasc Surg
(1998)
In vivo analysis of mechanical wall stress and abdominal aortic aneurysm rupture risk
J Vasc Surg
Novel insights into the mechanisms and treatment of intramural hematoma affecting the entire thoracic aorta
Ann Thorac Surg
The neural crest as a possible pathogenetic factor in coarctation of the aorta and bicuspid aortic valve
J Thorac Cardiovasc Surg
Acute aortic dissection: perspectives from the International Registry of Acute Aortic Dissection (IRAD)
Eur J Vasc Endovasc Surg
Toward a biomechanical tool to evaluate rupture potential of abdominal aortic aneurysm: identification of a finite strain constitutive model and evaluation of its applicability
J Biomech
Thoracic aortic aneurysms: a population-based study
Surgery
Contemporary management of descending thoracic and thoracoabdominal aortic aneurysms: endovascular versus open
Circulation
Cited by (108)
Biomechanics of abdominal aortic aneurysm in the framework of Windkessel effect and fully-developed inflow velocity via two-way non-linear FSI
2023, International Journal of Non-Linear MechanicsA review on the biomechanical behaviour of the aorta
2023, Journal of the Mechanical Behavior of Biomedical MaterialsPredicting the Risk of Type B Aortic Dissection Using Hemodynamic Parameters in Aortic Arches: A Comparative Study between Healthy and Repaired Aortas
2023, Computer Methods and Programs in BiomedicineCitation Excerpt :The results show that more pathological anatomical feathers, such as severe angulation, tortuosity, and elongation, can be observed in the repaired aortas adopted in this study. This finding was consistent with existing studies, that these pathological anatomical features can lead to the enhancement of hemodynamic force on the vessel wall or weaken the aortic wall, which may further result in the formation of AD [5,7,33,34]. However, the aforementioned features are difficult to accurately predict the risk of AD due to the inability of quantification [3].
Association of diameter and wall stresses of tricuspid aortic valve ascending thoracic aortic aneurysms
2022, Journal of Thoracic and Cardiovascular SurgeryRisk evaluation of type B aortic dissection based on WSS-based indicators distribution in different types of aortic arch
2022, Computer Methods and Programs in Biomedicine