1Venous thromboembolism: Epidemiology and magnitude of the problem
Section snippets
Relationship between VTE and atherothrombosis
VTE and atherothrombosis share common risk factors (Table 1) and the common pathophysiology of inflammation, hypercoagulability, and endothelial injury [34]. A meta-analysis of cardiovascular risk factors and VTE in more than 63,000 patients in cohort or case–control studies found that compared with control subjects, the odds ratio for the risk of VTE was 2.33 for obesity, 1.51 for hypertension, 1.42 for diabetes mellitus, 1.18 for cigarette smoking [35], and 1.16 for hypercholesterolemia [36].
Risk factors for VTE
VTE is a multifactorial disorder that arises as a result of genetic and environmental factors that interact. Inherited thrombophilias are frequently suspected in patients with VTE at a young age, multiple family members with VTE, idiopathic or recurrent VTE, or recurrent spontaneous abortions. Major inherited thrombophilias include factor V Leiden, prothrombin gene mutation 20210, and deficiencies of protein C, protein S, or antithrombin. Prevalence of inherited thrombophilias varies by
Conflict of interest
Dr. Goldhaber discloses the following possible conflicts: Research support from Daiichi Sankyo, Eisai, and EKOS, Johnson & Johnson, and Sanofi Aventis.
Dr. Goldhaber serves as a Consultant for: Baxter, Boehringer Ingelheim, Bristol Myers Squibb, Daiichi Sankyo, Eisai, Medscape, Merck Portola, and Sanofi Aventis.
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