Noninvasive quantification of regional myocardial function using Doppler-derived velocity, displacement, strain rate, and strain in healthy volunteers: effects of aging
Section snippets
Population
The institutional review board on human research approved this study, and all participants gave informed consent. Healthy volunteers free of any known cardiovascular disease between the ages of 18 and 76 years were recruited. All volunteers underwent a thorough history, physical examination, and had a normal electrocardiogram. None of them reported taking any kind of cardioactive medications (except aspirin).
Echocardiographic study
A complete echocardiographic study was performed on all participants using an
Results
In all, 100 healthy volunteers were recruited. The mean age was 43 ± 15 years (range: 18-76 years) and 52 (52%) were men. There were 22 (21.5%) participants between 18 and 29 years old, 23 (22.5%) between 30 and 39 years, 26 (26%) between 40 and 49 years, 14 (14%) between 50 and 59 years, and 15 (15%) above 60 years. Their resting heart rates varied between 44 and 86 bpm (mean 66 ± 11 bpm), and their blood pressure varied from 80 to 120/60 to 80 mm Hg (mean 110 ± 10/70 ± 10 mm Hg).
Discussion
In this study, we report normal age-adjusted values for systolic tissue velocity, displacement, strain rate, and strain as measured by DTE. Differences in acquired data between the segments of individual walls are demonstrated, as are gradual changes in these values with age. Reproducibility of these measurements and the agreement of the measurements between 2 readers were acceptable, indicating that these techniques can be implemented into the clinical practice.
References (24)
- et al.
Color Doppler myocardial imaginga new technique for the assessment of myocardial function
J Am Soc Echocardiogr
(1994) - et al.
New method for evaluating left ventricular wall motion by color-coded tissue Doppler imagingin vitro and in vivo studies
J Am Coll Cardiol
(1995) - et al.
Quantitative Doppler tissue imaging for assessment of regional myocardial velocities during transient ischemia and reperfusion
Am Heart J
(1996) - et al.
Real-time strain rate imaging of the left ventricle by ultrasound
J Am Soc Echocardiogr
(1998) - et al.
Abnormal postsystolic thickening in acutely ischemic myocardium during coronary angioplastya velocity, strain, and strain rate Doppler myocardial imaging study
J Am Soc Echocardiogr
(1999) - et al.
Assessment of regional longitudinal myocardial strain rate derived from Doppler myocardial imaging indexes in normal and infarcted myocardium
J Am Soc Echocardiogr
(2000) - et al.
Myocardial Doppler velocity imaging–a quantitative technique for interpretation of dobutamine echocardiography
Am J Cardiol
(1998) - et al.
Can natural strain and strain rate quantify regional myocardial deformation? A study in healthy subjects
Ultrasound Med Biol
(2001) - et al.
Abnormal left ventricular filling with increasing age reflects abnormal myocardial characteristics independent of ischemia or hypertrophy
Am J Cardiol
(2003) - et al.
Perspectives on mammalian cardiovascular aginghumans to molecules
Comp Biochem Physiol A Mol Integr Physiol
(2002)