Blood oxidative stress biomarkers: influence of sex, exercise training status, and dietary intake
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2021, Free Radical Biology and MedicineCitation Excerpt :Probably, the increased antioxidant defense resulted in a lower intensity of oxidative stress in women compared to men. Indeed, lower plasma concentrations of DNA, proteins and lipids oxidative damage products have been reported in the female sex [59,61,63]. In our study, we also observed elevated concentration of lipid and protein oxidative damage products in morbidly obese patients of both genders, whose increased with ages.
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2021, Microvascular ResearchCitation Excerpt :In premenopausal females, the presence of estrogen is capable of improving NO bioavailability via its antioxidant-like effect (Borrás et al., 1802; Orshal and Khalil, 2004) and ability to increase NO production (Pabbidi et al., 2018). Also, it has been reported that young healthy females display lower oxidative stress compared to age-matched males (Bloomer and Fisher-Wellman, 2008; Ide et al., 2002), with prior animal studies suggesting this may be due to lower expression of NADPH enzymes (Miller et al., 2007; Wong et al., 2015). This contention was examined within a subset of subjects in the current study (females: n = 6; males: n = 7), with young females demonstrated 54% lower blood superoxide levels compared to the young males, a finding that carried a high effect size (0.7), but did not reach significance (p = 0.2) due to a low sample size.