Clinical ResearchClinical TrialSafety and Efficacy of Sertraline for Depression in Patients With Heart Failure: Results of the SADHART-CHF (Sertraline Against Depression and Heart Disease in Chronic Heart Failure) Trial
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The SADHART-CHF study was funded by the National Institute of Mental Health(NIMH), Bethesda, Maryland. Sertraline was supplied by Pfizer, Inc., New York, New York. Pfizer had no other role in any aspect of the study. Dr. O'Connor has received grants or research funding from Pfizer, Inc.and received salary support through the NIMHresearch grant. Dr. Jiang received salary support through the NIMHresearch grant and has received funding from Pfizer, Inc.to study nonpharmacologic intervention in depression improvement and the effects of pregabalin on the autonomic nervous system of patients with diabetes. Dr. Kuchibhatla has received salary support through an NIMHresearch grant. Dr. Silva receives honoraria from Pfizer, Inc.related to work as a Data Safety Monitoring Board member, providing Data Safety Monitoring Board oversight of 4 pediatric mental health trials that do not involve sertraline, the medication studied in SADHART-CHF. He also received salary support through the NIMHresearch grant. Dr. Cuffe is a consultant to Novartis and GlaxoSmithKline and receives honoraria from Novartis and GlaxoSmithKline. He also received salary support through the NIMHresearch grant. Dr. Callwood (Callwood Cardiology) received salary support through the NIMHresearch grant. Drs. Zakhary and Stough report that they have no relationships to disclose. Ms. Arias received salary support through the NIMHresearch grant. Dr. Rivelli received salary support through the NIMHresearch grant. Dr. Krishnan is a consultant to Amgen, Bristol-Myers Squibb, CeNeRx, Corcept, GlaxoSmithKline, Johnson & Johnson, Lundbeck, Merck, Organon, Pfizer, Sepracor, and Wyeth, and received salary support through the NIMHresearch grant.