Original articleRelation between degree of weight loss after bariatric surgery and reduction in albuminuria and C-reactive protein
Section snippets
Methods
The study sample consisted of 109 consecutive morbidly obese patients (BMI >40 kg/m2 without diabetes or a BMI >35 kg/m2 with diabetes) from a previous study evaluating cardiopulmonary fitness for bariatric surgery [7]. These patients were evaluated at the William Beaumont Hospital Weight Control Center (Royal Oak, MI) and underwent laparoscopic Roux-en-Y gastric bypass from December 2002 to December 2003. None of the patients had overt cardiovascular or renal disease (i.e., cardiac
Results
The 62 patients in our study had a mean age of 46.1 ± 10.1 years; 51 (82.3%) were women, and 58 (93.5%) were white (Table 1). Baseline hypertension was present in 26 patients (41.9%), and type 2 diabetes mellitus in 25 (40.3%). Table 1 lists the additional baseline characteristics of the study sample. The median follow-up duration was 14.8 months (interquartile range 9.9–23.8). After bariatric surgery, the mean weight loss was −41.2 ± 13.8 kg, and the BMI decreased from 49.2 ± 8.7 kg/m2 to 34.1
Discussion
We found a reduction in albuminuria and hs-CRP in obese patients with weight loss after bariatric surgery. In addition, the trend toward a greater reduction in the cardiovascular biomarkers with increased surgical weight loss was found to be nonsignificant for albuminuria but significant for hs-CRP.
Obesity is intimately interconnected to multiple risk factors for cardiovascular disease, including diabetes, hypertension, hyperlipidemia, the metabolic syndrome, and obstructive sleep apnea [1].
Conclusion
Obesity is a significant risk factor in the natural history of cardiovascular disease. Bariatric surgery offers patients with morbid obesity an opportunity to resolve or significantly improve diabetes, hypertension, and hyperlipidemia. In addition, albuminuria and hs-CRP decrease with weight loss after bariatric surgery, with a greater reduction in hs-CRP with increased surgical weight loss. Future prospective studies are needed to determine whether the metabolic changes with medical or
Disclosures
The authors claim no commercial associations that might be a conflict of interest in relation to this article.
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This study was accepted in part for poster presentation at the American Society for Metabolic and Bariatric Surgery Annual Meeting, Washington DC, June 2008 (Surg Obes Relat Dis 2008;4:324).