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Enlarged right ventricular size at 11 years’ follow-up after closure of secundum-type atrial septal defect in children

Published online by Cambridge University Press:  17 April 2012

Wilfred B. de Koning ,
Lennie M. van Osch-Gevers ,
Danielle Robbers-Visser ,
Ron T. van Domburg ,
Ad J.J.C. Bogers  and
Willem A. Helbing
Wilfred B. de Koning
Affiliation:
Division of Cardiology, Department of Paediatrics, Erasmus University Medical Centre – Sophia Children's Hospital, Rotterdam, The Netherlands Department of Radiology, Erasmus University Medical Centre – Sophia Children's Hospital, Rotterdam, The Netherlands
Lennie M. van Osch-Gevers
Affiliation:
Division of Cardiology, Department of Paediatrics, Erasmus University Medical Centre – Sophia Children's Hospital, Rotterdam, The Netherlands
Danielle Robbers-Visser
Affiliation:
Division of Cardiology, Department of Paediatrics, Erasmus University Medical Centre – Sophia Children's Hospital, Rotterdam, The Netherlands Department of Radiology, Erasmus University Medical Centre – Sophia Children's Hospital, Rotterdam, The Netherlands
Ron T. van Domburg
Affiliation:
Department of Cardiology, Erasmus University Medical Centre, Rotterdam, The Netherlands
Ad J.J.C. Bogers
Affiliation:
Department of Cardiothoracic Surgery, Erasmus University Medical Centre, Rotterdam, The Netherlands
Willem A. Helbing*
Affiliation:
Division of Cardiology, Department of Paediatrics, Erasmus University Medical Centre – Sophia Children's Hospital, Rotterdam, The Netherlands Department of Radiology, Erasmus University Medical Centre – Sophia Children's Hospital, Rotterdam, The Netherlands
*
Correspondence to: Professor W. A. Helbing, Departments of Paediatrics and Radiology, Division of Cardiology, Erasmus University Medical Centre – Sophia Children's Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands. Tel: +31104636264; Fax: +31104636801; E-mail: w.a.helbing@erasmusmc.nl
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Abstract

Background

The fate of right ventricular dimensions after surgical closure of secundum-type atrial septal defects remains unclear. The objectives of this study were to assess ventricular dimensions, exercise capability, and arrhythmias of patients operated for secundum-type atrial septal defect and compare the results with those in healthy references.

Methods

A total of 78 consecutive patients underwent surgical closure for a secundum-type atrial septal defect between 1990 and 1995. In all, 42 patients were included and underwent a cross-sectional evaluation including echocardiography, magnetic resonance imaging, exercise testing, and 24-hour ambulatory electrocardiography. Patients were matched with healthy controls for gender, body surface area, and age.

Results

The mean age at surgery was 4.6 plus or minus 2.8 years, and the mean age at follow-up was 16 plus or minus 3 years. There were no residual intracardiac lesions. The mean right ventricular end-systolic volume was significantly larger in patients (142 ± 26 millilitres) than in references (137 ± 28 millilitres; p = 0.04). In 25% of the patients, right ventricular end-systolic volume was larger than the 95th percentile for references. No relevant arrhythmias were detected. Exercise testing did not reveal differences with healthy references: maximal power (169 ± 43 Watt patients versus 172 ± 53 controls; p = 0.8), maximal oxygen uptake (38 ± 8 versus 41 ± 13 millilitres per minute per kilogram; p = 0.1).

Comment

After surgical closure of secundum-type atrial septal defect, right ventricular end-systolic volume is increased. These findings have no impact on rhythm status or exercise capacity at this stage of follow-up, but may have implications for the timing of surgery or the technique of closure if confirmed in longer follow-up.

Keywords

Congenital heart diseaseseptal defectsmagnetic resonance imagingoutcomes (includes mortality, morbidity)arrhythmia
Type
Original Article
Information
Cardiology in the Young , Volume 23 , Issue 1 , February 2013 , pp. 7 - 13
Copyright
Copyright © Cambridge University Press 2012

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