Skip to main content
SpringerLink
Log in

Detection of diastolic dysfunction: acoustic quantification (AQ) in comparison to Doppler echocardiography

  • Published:
The International Journal of Cardiac Imaging Aims and scope Submit manuscript

Abstract

Objectives. To evaluate the potential of acoustic quantification (AQ) in detection of diastolic dysfunction in comparison to Doppler analysis, we investigated, as a model of restrictive filling pattern, nonrejecting heart transplant recipients early postoperatively. Background. AQ, an ultrasonic backscatter imaging system, enables inst-antaneous calculation of cavity areas and thus provides a new approach to diastolic function. Methods. Of 27 pts who have undergone heart transplantation, echocardiography has been performed at the day of biopsy. During a time course of 8 weeks echocardiographic data have been analysed at 3 different time points (early, mid and late) in 16 nonrejecting pts. Indexes of the area-change waveform and its 1. derivative (dA/dt) obtained by AQ were opposed to usual Doppler indexes. Results. In comparing data of the early and late time point of investigation, significant changes of early diastolic filling were detectable by AQ as well as by Doppler: End-diastolic areas have increased (p<0.001), while peak filling rate (p<0.0001), slope of area change during rapid filling (p<0.001) and amount of relative area change during rapid filling (p<0.001) have decreased. Complementary, Doppler derived pressure half-time (p<0.0001) and isovolumic relaxation time (p<0.0001) have increased while the peak early filling velocity (p<0.0001) and its time velocity integral (p<0.001) have decreased. Conclusion. An initial restrictive filling pattern has improved 8 weeks postoperatively. Since multiple indexes, obtained from the area change waveforms, in particular the for end-diastolic area normalized peak filling rate, seem to be highly sensitive in detecting changes of diastolic function, AQ may play an important complementary role in non-invasive evaluation of restrictive filling pattern.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. St.Goar FG, Gibbons R, Schnittger I, Valantine HA, Popp RL. Left ventricular diastolic function. Doppler echocardiographic changes soon after transplantation. Circulation 1990; 82: 872-878.

    Google Scholar 

  2. Appleton CP, Hatle LK, Popp RL. Demonstration of restrictive ventricular physiology by Doppler echocardiography. J Am Coll Cardiol 1988; 11: 757-768.

    Google Scholar 

  3. Skowronki EW, Epstein M, Ota D, Hoagland PM, Gordon JB Adamson RM et al. Right and left ventricular function after cardiac transplantation. Changes during and after rejection. Circulation 1991; 84: 2409-2417.

    Google Scholar 

  4. Valentine HA, Appleton CP, Hatle LK, Hunt SA, Billingham ME, Shumway NE et al. A hemodynamic and Doppler echocardiographic study of ventricular function in long-term cardiac allograft recipients. Circulation 1989; 79: 66-75.

    Google Scholar 

  5. Amende I, Simon R, Seegers A, Daniel W, Heublein B, Hetzer R et al. Diastolic dysfunction during acute cardiac allograft rejection. Circulation 1990; 81Suppl 3: 66-70.

    Google Scholar 

  6. Störk T, Walkowiak T, Siniawski H, Danne O, Müller R, Möckel M et al. Nichtinvasive Erfassung der akuten Abstoßungsreaktion nach Herztransplantation mittels Dopplerund M-Mode-Echokardiographie: Vorläufige Ergebnisse einer prospektiven Untersuchung. Z Kardiol 1990; 79: 758-765.

    Google Scholar 

  7. Hausmann B, Voigt B, Hach H, Simon R. Dynamische On-line Quantifizierung der linksventrikulären Funktion durch automa-tische Konturerkennung (ABD): Validierung einer neuen echokardiographischen Methode. Z Kardiol 1994; 83: 548-555.

    Google Scholar 

  8. Hausmann B, Hach H, Voigt B, Simon R. Echokardiographische Online Quantifizierung der links-und rechtsventrikulären Funktion durch automatische Konturerkennung (ABD): Referenzwerte und Reproduzierbarkeit bei gesunden Probanden. Z Kardiol 1994; 83: 556-561.

    Google Scholar 

  9. Lindower PD, Rath L, Preslar J, Burns TL, Rezai K, Vandenberg B. Quantification of left ventricular function with an automated border detection system and comparison with radionuclide ventriculography. Am J Cardiol 1994; 73: 195-199.

    Google Scholar 

  10. Marcus RH, Bednarz J, Coulden R, Shroff S, Lipton M, Lang RM. Ultrasonic backscatter system for automated on-line endocardial boundary detection: Evaluation by ultrafast computed tomography. J Am Coll Cardiol 1993; 22: 839-847.

    Google Scholar 

  11. Mügge A, Grote J, Hausmann D, Niedermeyer J, Daniel WG. Akustische Quantifizierung — ein neues On-line-Verfahren zur automatischen Erfassung von linksventrikulären Flächen und Flächenänderungen im Echokardiogramm. Z Kardiol 1992; 81: 681-686.

    Google Scholar 

  12. Perez JE, Waggoner AD, Barzilai B; Melton HE, Miller JG, Sobel BE. On-line-assessment of ventricular function by automatic boundary detection and ultrasonic backscatter imaging. J Am Coll Cardiol 1992; 19: 313-320.

    Google Scholar 

  13. Vandenberg BF, Rath LS, Stuhlmuller P, Melton HE, Skorton DJ. Estimation of left ventricular cavity area with an on-line semiautomated echo-cardiographic edge detection system. Circulation 1992; 86: 159-166.

    Google Scholar 

  14. Chenzbraun A, Pinto FJ, Popylisen S, Schnittger I, Popp, R. Filling pattern in left ventricular hypertrophy: A combined acoustic quantification and Doppler study. J Am Coll Cardiol 1994; 23: 1179-85.

    Google Scholar 

  15. Chenzbraun A, Pinto FJ, Popylisen S, Schnittger I, Popp, R. Comparison of acoustic quantification and Doppler echocardiography in assessment of left diastolic variables. Br Heart J 1993; 70: 448-456.

    Google Scholar 

  16. Sahn DJ, DeMaria A, Kisslo J, Weyman AE. The Comittee on M-Mode Standardization of the American Society of Echocardiography: Recommendations regarding quantification of M-mode echocardiographic measurements. Circulation 1978; 58(20): 1072-1083.

    Google Scholar 

  17. Kemnitz J, Cohnert T, Schäfers H-J, Helmke M, Wahlers T, Herrmann G et al. A. A Classification of Cardiac Allograft Rejection. A modification of the classification by Billingham. Am J Surgical Pathol 1987; 11Suppl 7: 503-515.

    Google Scholar 

  18. Nishimura RA, Housmans PR, Hatle LK, Tajik AJ. Assessment of diastolic function of the heart: background and current applications of Doppler Echocardiography. Part I. Physiologic and pathophysiologic features. Mayo Clin Proc 1989; 64: 71-81.

    Google Scholar 

  19. Nishimura RA, Housmans PR, Hatle LK, Tajik AJ. Assessment of diastolic function of the heart: background and current applications of Doppler Echocardiography. Part II. Clinical studies. Mayo Clin Proc 1989; 64: 181-204.

    Google Scholar 

  20. Giannuzzi P, Imparato A, Temporelli PL, DeVita F, Silva PL, Scapellato F et al. Doppler-derived mitral deceleration time of early filling as a strong predictor of pulmonary capillary wedge pressure in postinfarction patients with left ventricular systolic dysfunction. J Am Coll Cardiol 1994; 23: 1630-1637.

    Google Scholar 

  21. Rokey R, Kuo LC, Zoghbi WA, Limacher MC, Quinones MA. Determination of parameters of left ventricular diastolic filling with pulsed Doppler echocardiography: Comparison to cineangiography. Circulation 1985: 71: 543-550.

    Google Scholar 

  22. Sapin PM, Xie G, Smith. Peak emptying and peak filling rates derived from automatic border detection echocardiography: comparison with cineventriculography (abstract). J Am Coll Cardiol 1993; 2: 917-99.

    Google Scholar 

  23. Corcos T, Tamburino C, Leger P, Vaisser E, Rossant P, Mattei MF, et al. Early and late hemodynamic evaluation after cardiac transplantation: A study of 28 cases. J Am Coll Cardiol 1988; 11: 264-269.

    Google Scholar 

  24. Muurling S, Hausmann B, Haverich A, Simon R. Automatische Konturerkennung (ABD): Neue echokardiographische Parameter in der Diagnostik akuter Abstoßungskrisen bei Herztransplantierten (abstract). Z Kardiol 1996 85Suppl 2: 56-195.

    Google Scholar 

  25. Berwing K, Friedl A, Schaper J, Huth C, Schwarz T, Klövekorn WP et al. Doppler-und echokardiographische Parameter zum Nachweis akuter Abstoßungen nach Herztransplantation. Z Kardiol 1994; 83: 225-233.

    Google Scholar 

  26. Ciliberto GR, Mascarello M, Grondo E, Bonacina E, Anjos MC, Danzi G et al. Acute rejection after heart transplantation: Noninvasive echocardiographic evaluation. J Am Coll Cardiol 1994; 23: 1156-1161.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cardiology, University Hospital, Christian-Albrechts-University of Kiel, 24105, Kiel, Germany

    Beate Hausmann, Stella Muurling & Rüdiger Simon

  2. Department of Nuclear Medicine, University Hospital, Christian-Albrechts-University of Kiel, 24105, Kiel, Germany

    Catharina Stauch

  3. Department of Cardiac Surgery, University Hospital, Christian-Albrechts-University of Kiel, 24105, Kiel, Germany

    Axel Haverich & Stephan Hirt

Authors
  1. Beate Hausmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stella Muurling
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Catharina Stauch
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Axel Haverich
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Stephan Hirt
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Rüdiger Simon
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hausmann, B., Muurling, S., Stauch, C. et al. Detection of diastolic dysfunction: acoustic quantification (AQ) in comparison to Doppler echocardiography. Int J Cardiovasc Imaging 13, 301–310 (1997). https://doi.org/10.1023/A:1005791512974

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1005791512974

Search

Navigation