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Electrical Impedance Properties of Normal and Chronically Infarcted Left Ventricular Myocardium

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Abstract

Background: Previous reports have disclosed that a significant difference exists between the electrical impedance properties of healthy and chronically infarcted ventricular myocardium.

Purpose: To assess the potential utility of electrical impedance as the basis for mapping in chronically infarcted left ventricular myocardium. Specifically: (1) to delineate electrical impedance properties of healthy and chronically infarcted ventricular myocardium, with special emphasis on the infarction border zone; (2) to correlate impedance properties with tissue histology; (3) to correlate impedance properties with electrogram amplitude and duration; (4) To demonstrate that endocardial impedance can be measured effectively in vivo using an electrode mounted on a catheter inserted percutaneously.

Methods: An ovine model of chronic left ventricular infarction was utilized. Sites of healthy myocardium, densely infarcted myocardium and the infarction border zone were investigated. Bulk impedance was measured in vitro using capacitor cell, four-electrode and unipolar techniques. Epicardial and endocardial impedances were measured in vivo using four-electrode and unipolar techniques. Impedance was measured at multiple frequencies. Electrographic amplitude, duration and amplitude/duration ratio were measured using bipolar electrograms during sinus rhythm. Quantitation of tissue content of myocytes, collagen, elastin and neurovascular elements was performed.

Results: Densely infarcted myocardial impedance was significantly lower than healthy myocardium. Impedance gradually decreased in the border zone transitioning between healthy myocardium and dense infarction. Decreasing impedance correlated with a decrease in tissue myocyte content. The magnitude of the difference in impedance between densely infarcted and healthy myocardium increased as the measurement frequency decreased. Healthy myocardium exhibited a marked frequency dependence in its impedance properties; this phenomenon was not observed in densely infarcted myocardium. There was a direct association between impedance and both electrogram amplitude and amplitude/duration ratio. There was an inverse association between impedance and electrogram duration. Endocardial impedance, measured in vivo using a electrode catheter inserted percutaneously, was demonstrated to distinguish between healthy and infarcted myocardium.

Conclusions: The electrical impedance properties of healthy and infarcted left ventricular myocardium differ markedly. The properties of the infarction border zone are intermediate between healthy and infarcted myocardium. Impedance may be a useful assay of cardiac tissue content and adaptable for cardiac mapping in vivo.

Condensed Abstract. To delineate the electrical impedance properties of healthy and chronically infarcted left ventricular myocardium emphasizing the infarction border zone, impedance was measured in chronically infarcted ovine hearts. Densely infarcted myocardial impedance was significantly lower than healthy myocardium. Impedance gradually decreased in the infarction border zone in transition between healthy myocardium and dense infarction. This correlated with a decreasing myocyte content. The magnitude of the difference in impedance between densely infarcted and healthy myocardium increased as measurement frequency decreased. There was a direct association between impedance and electrogram characteristics. Endocardial impedance, measured in vivo using an electrode catheter inserted percutaneously, distinguished between healthy and infarcted myocardium

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References

  1. Bolick DR, Hackel DB, Reimer KA. Quantitative analysis of myocardial infarct structure in patients with ventricular tachycardia. Circulation 1986;74(6):1266–1279.

    Google Scholar 

  2. Gardner PI, Ursell, PC, Fenoglio JJ, Wit AL. Electrophysiologic and anatomic basis for fractionated electrograms recorded from healed myocardial infarcts. Circulation 1985;72:596–605.

    Google Scholar 

  3. Fallert MA, Mirotznik MS, Downing SW, Savage EB, Foster KR, Josephson ME, Bogen DK. Myocardial electrical impedance mapping of ischemic sheep hearts and healing aneurysms. Circulation 1993;87:199–207.

    Google Scholar 

  4. Ellenby MI, Small KW, Wells RM, Hoyt DJ, Lowe JE. Online detection of reversible myocardial ischemic injury by measurement of myocardial electrical impedance. Ann Thorac Surg 1987;44:587–597.

    Google Scholar 

  5. Markovitz LJ, Savage EB, Ratcliffe MB, Bavaria JE, Kreiner G, Iozzo RV, Hargrove WC, Bogen DK, Edmunds LH Jr. Large animal model of left ventricular aneurysm. Ann Thorac Surg 1989;48:838–845.

    Google Scholar 

  6. Kreiner G, Gottlieb CD, Yeh IT, Furukawa S, Miller JM, Edmunds LH Jr, Bavaria JE, Bernstein RC, Hargrove WC, Tyson GS. Ventricular tachycardia in an ovine model of left ventricular aneurysm. Surg Forum 1989;40:219–223.

    Google Scholar 

  7. Kreiner G, Gottlieb CD, Furukawa S, Simson MB, Tyson GS, Edmunds LH Jr. Late potentials in an ovine model of transmural myocardial infarction. J Appl Physiol 1992;73(3):841–845.

    Google Scholar 

  8. Schwan HP. Determination of biological impedances. In: Physical Techniques in Biological Research. Volume 6. 1963,323–407.

    Google Scholar 

  9. Steendijk P, Mur G, Van Der Veld ET. The four-electrode resistivity technique in anisotropic media: theoretical analysis and application on myocardial tissue in vivo. IEEE Transactions on Biomedical Engineering 1993;40(11): 1138–1147.

    Google Scholar 

  10. Cassidy DM, Vasallo JA, Buxton AE, Doherty JU, Marchlinski FE, Josephson ME. The value of catheter mapping during sinus rhythm to localize the site of origin of ventricular tachycardia. Circulation 1984;69:1103–1110.

    Google Scholar 

  11. Josephson ME, Horowitz LN, Marchlinski FE. The role of catheter mapping in the preoperative evaluation of ventricular tachycardia. Am J Cardiol 1982;49:207–215.

    Google Scholar 

  12. Schwan HP. Electrical properties measured with alternating currents: Body tissues. In: Spector WS Jr, ed. Handbook of Biological Data. Philadelphia: WB Saunders, 1956.

    Google Scholar 

  13. Gabriel C. The dielectric properties of biological tissues: I. Literature survey. Phys Med Biol 1996;41:2231–2249.

    Google Scholar 

  14. Surowiec A, Stuchly SS, Eidus L, Swarup A. In vitro dielectric properties of human tissues at radiofrequencies. Phys Med Biol 1987;32:615–621.

    Google Scholar 

  15. Schwan HP. Linear and nonlinear electrode polarization and biological materials. Ann Biomed Res 1992;20:269–288.

    Google Scholar 

  16. Foster KR, Schwan HP. Dielectric properties of tissues and biological materials. A critical review. Critical Reviews in Biomedical Engineering 1989;17(1):25–104.

    Google Scholar 

  17. Kleber AG, Riegger CB, Janse MJ. Electrical uncoupling and increase of extracellular resistance after induction of ischemia in isolated, arterially perfused rabit papillary muscle. Circ Res 1987;61:271–279.

    Google Scholar 

  18. Cinca J, Warren M, Carreno A, Tresanchez M, Armadans L, Gomez P, Soler-Soler J. Changes in myocardial electrical impedance induced by coronary artery occlusion in pigs with and without preconditioning. Circ Res 1997;96 3079–3086.

    Google Scholar 

  19. DeBakker JMT, Van Capelle FJL, Janse MJ, Wilde AAM, Coronel R, Becker AE, Dingemans KP, Van Hemel NM, Hauer RNW. Reentry as a cause of ventricular tachycardia in patients with chronic ischemic heart disease: Electrophysiologic and anatomic correlation. Circulation 1988;77(3):589–600.

    Google Scholar 

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Authors and Affiliations

  1. Cardiovascular Research Laboratory, Philadelphia Heart Institute, USA

    David Schwartzman & John J. Michele

  2. Department of Bioengineering, University of Pennsylvania, USA

    Isaac Chang & Kenneth R. Foster

  3. Department of Electrical Engineering, Catholic University of America, USA

    Mark S. Mirotznik

Authors
  1. David Schwartzman
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  2. Isaac Chang
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  3. John J. Michele
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  4. Mark S. Mirotznik
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  5. Kenneth R. Foster
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Schwartzman, D., Chang, I., Michele, J.J. et al. Electrical Impedance Properties of Normal and Chronically Infarcted Left Ventricular Myocardium. J Interv Card Electrophysiol 3, 213–224 (1999). https://doi.org/10.1023/A:1009887306055

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