Abstract
MALES stand at risk in many pathological states1, especially cardiovascular disease, in which there is a statistically significant higher mortality in men than women2. We have described3 a sex difference in platelet responsivity in rats and guinea pigs where platelets from males were significantly more sensitive to aggregating stimuli than those from females. Increased platelet responsiveness has been detected in humans,in thromboembolic disease4 and after acute myocardial infarction5. Indeed, the principal post mortem finding in subjects who died suddenly is occlusion in the pulmonary circulation due to platelet aggregation6. We have suggested3 that platelet sensitivity is mediated by the androgenic steroids and that androgens contribute to the incidence of thrombotic disease.
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JOHNSON, M., RAMEY, E. & RAMWELL, P. Sex and age differences in human platelet aggregation. Nature 253, 355–357 (1975). https://doi.org/10.1038/253355a0
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DOI: https://doi.org/10.1038/253355a0
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