Original InvestigationPathogenesis and Treatment of Kidney DiseaseKidney Disease After Preeclampsia: A Systematic Review and Meta-analysis
Section snippets
Methods
We followed the MOOSE (Meta-analysis of Observational Studies in Epidemiology) consensus statement for reporting of meta-analysis of observational studies.21
Results
As shown in Fig 1, a total of 1,243 nonduplicate titles and abstracts were identified in our searches. Based on our screening process, 116 citations were selected to undergo full-text article review. The most common reasons for exclusion were study design and failure to report kidney outcomes.
Seven studies26, 27, 28, 29, 30, 31, 32 (all cohort) were included, involving 273 patients with preeclampsia and 333 patients with uncomplicated pregnancies at a weighted mean follow-up of 7.1 years
Discussion
In this systematic review and meta-analysis, we determined that after a pregnancy complicated by preeclampsia, approximately 31% of women had microalbuminuria compared with 7% of women with uncomplicated pregnancies. This prevalence of microalbuminuria 7 years after preeclampsia is similar to that found in patients with type 1 diabetes mellitus (28% at 14 years after diagnosis),33 whereas the prevalence after uncomplicated gestations was similar to that reported in the general population in the
Acknowledgements
We gratefully acknowledge the assistance in developing the search strategy by Ms Elizabeth Uleryk, Chief Librarian, Hospital for Sick Children, Toronto, Canada; and our translators, including Angelina Krol, Christian Schlosser, Issei Nakamura, Iman Aouf, Alex Lagunov, and Emilija Makaji.
Support: Drs McDonald and Devereaux are each supported by a Canadian Institutes of Health Research New Investigator Award. Dr Han is supported by a State Scholarship Fund by the China Scholarship Council. Dr
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Originally published online as doi:10.1053/j.ajkd.2009.12.036 on March 26, 2010.