Trial DesignProphylactic intravenous use of milrinone after cardiac operation in pediatrics (PRIMACORP) study☆
Section snippets
Study organization
The study design and supervision of the PRIMACORP trial is the responsibility of the Steering Committee, Clinical Endpoint Committee, and Data Safety Monitoring Board (DSMB). In addition to the protocol development, the role of the Steering Committee is to provide academic leadership for the overall conduct of the trial, which includes interpreting and disseminating the results. The DSMB is responsible for overseeing the safety of PRIMACORP participants. The Clinical Endpoint Committee, a
Discussion
Because of the strong relationship between a drop in cardiac index and the possibility of cardiac death, it is imperative that LCOS be identified and treated.3 Parr et al4 evaluated 139 infants and small children ≤48 months old for 72 hours after intracardiac surgery. The mortality rate was 19.4% (n = 27), and more than half the deaths were caused by acute cardiac failure and were associated with a low cardiac index (<2.0 L/min/m2). Wernovsky et al7 evaluated 171 pediatric patients <3 months
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Cited by (145)
Contemporary Multicenter Outcomes for Truncus Arteriosus With Interrupted Aortic Arch
2023, Annals of Thoracic SurgeryCitation Excerpt :In-hospital mortality was 48% for patients who underwent an operation, which was attributed to low cardiac output in most cases. Advances in imaging, surgical techniques, and the prevention, detection, and management of low cardiac output (eg, milrinone usage, improvement in pediatric cardiac intensive care) may be partially responsible for continued improvement in the outcomes observed in our study and other single-center reports.5,13-15 The median age of admission in the Congenital Heart Surgeons Society study was 4 days, and congestive heart failure was a presenting symptom in 34% of patients.
Unique Challenges of Randomised Controlled Trials in Pediatric Cardiology
2021, Canadian Journal of CardiologyCardiac critical care of the post-operative congenital heart disease patient
2021, Seminars in Pediatric SurgeryCardiopulmonary Bypass and Management
2019, A Practice of Anesthesia for Infants and ChildrenAnesthesia for Children Undergoing Heart Surgery
2019, A Practice of Anesthesia for Infants and Children
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Reprint requests: Gil Wernovsky, MD, Children's Hospital of Philadelphia, Division of Cardiology, 34th and Civic Center Boulevard, Philadelphia, PA 19104. E-mail: [email protected]