Congestive Heart FailurePolymorphisms of the β1-adrenergic receptor predict exercise capacity in heart failure☆,☆☆,★
Section snippets
Patients
The study was approved by the Institutional Review Board of the University of Cincinnati College of Medicine. The group consisted of 263 unrelated sequential white patients with ischemic (n = 111) or idiopathic dilated cardiomyopathy (n = 152) (aged 48.9 ± 1.0 years, New York Heart Association functional class II-IV, left ventricular ejection fraction 26.0% ± 0.8%, 74.5% male) referred to the University of Cincinnati Heart Failure/Transplant Program. At the time of entry into the study,
Results
Table I shows the clinical characteristics of the patients stratified by β1AR genotypes.At position 389, there were 23 homozygous Gly389 patients, 105 heterozygotes, and 135 patients who were homozygous for Arg 389. Table II and Figure 1 show the results from the exercise studies in the 3 groups.
Discussion
In this work we found that patients with heart failure with the homozygous Gly389 β1AR polymorphism have significantly depressed exercise performance compared with those with the Arg389 β1AR. Heterozygotes had an intermediate level of performance. A smaller contribution to exercise performance in these patients were the polymorphisms at amino acid position 49. The greatest predictive β1AR genotypes were those that included position 49 and 389 polymorphisms. Importantly, these patients could not
Acknowledgements
We thank Esther Getz for assistance in manuscript preparation.
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Cited by (0)
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Supported by NIH grants HL52318, HD07463, and ES06096.
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Reprint requests: Stephen B. Liggett, MD, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Room G167, Cincinnati, OH 45267-0564.
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E-mail: [email protected]