Journal of the American Society of Echocardiography
Original ArticlesQuantitative parameters of myocardial perfusion with contrast echocardiography in human beings: Influence of triggering mode*
Section snippets
Study population
The study population consisted of 22 patients (16 men, mean age 58 ± 15 years) with suspected or known coronary artery disease. Thirteen patients had a prior myocardial infarction. The study was approved by the institutional review board of Baylor College of Medicine. All patients gave written informed consent to the study protocol. Patients were not eligible for the study if they met any of the following criteria: (1) known or suspected hypersensitivity to blood, blood products, or albumin,
Effect of continuous imaging and triggering mode on contrast intensity
Fifteen patients underwent single and dual triggering and 7 patients underwent single and triple triggering. MCI could be quantitated in 53 (88%) of the 60 potential myocardial segments of the 15 patients with dual triggering, and in 18 (64%) of potential segments of the 7 patients with dual triggering. Contrast intensity replenishment curves of a patient with single and dual triggering (Figure 2) and another with single and triple triggering (Figure 3) are shown.
Discussion
There are 2 main findings of the current study investigation: (1) The flash subtraction method with dual or triple triggering significantly alters the quantitative contrast-echocardiography parameters of myocardial velocity and blood flow. This occurs even if no subtraction of intensity is performed using the flash method. (2) Continuous imaging can be used for background subtraction because it destroys enough microbubbles for MCI to be similar to precontrast imaging. A second-best approach for
Acknowledgements
The authors would like to acknowledge Ms Hema P. Ramnauth and Ms Linda Pander for their expert secretarial help in preparing the manuscript and graphs.
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Reprint requests: William A. Zoghbi, MD, Baylor College of Medicine, 6550 Fannin, SM-677, Houston, TX 77030 (E-mail: [email protected]).