Comparison by Optical Coherence Tomography of Paclitaxel-Eluting Stents With Sirolimus-Eluting Stents Implanted in One Coronary Artery in One Procedure – 6-Month Follow-up –

Naoki Miyoshi; Junya Shite; Toshiro Shinke; Hiromasa Otake; Yusuke Tanino; Daisuke Ogasawara; Takahiro Sawada; Hiroyuki Kawamori; Hiroki Kato; Naoki Yoshino; Amane Kozuki; Ken-ichi Hirata

doi:10.1253/circj.CJ-09-0690

Cardiovascular Intervention

Comparison by Optical Coherence Tomography of Paclitaxel-Eluting Stents With Sirolimus-Eluting Stents Implanted in One Coronary Artery in One Procedure

– 6-Month Follow-up –

Naoki Miyoshi, Junya Shite, Toshiro Shinke, Hiromasa Otake, Yusuke Tanino, Daisuke Ogasawara, Takahiro Sawada, Hiroyuki Kawamori, Hiroki Kato, Naoki Yoshino, Amane Kozuki, Ken-ichi Hirata

Author information

Naoki Miyoshi
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
Junya Shite
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
Toshiro Shinke
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
Hiromasa Otake
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
Yusuke Tanino
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
Daisuke Ogasawara
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
Takahiro Sawada
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
Hiroyuki Kawamori
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
Hiroki Kato
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
Naoki Yoshino
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
Amane Kozuki
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
Ken-ichi Hirata
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine

Keywords: Neointima, Optical coherence tomography, Paclitaxel-eluting stent, Peri-strut low intensity, Sirolimus-eluting stent

JOURNAL FREE ACCESS

2010 Volume 74 Issue 5 Pages 903-908

DOI https://doi.org/10.1253/circj.CJ-09-0690

View "Advance Publication" version (March 10, 2010).

Details

Abstract

Background: Differences between paclitaxel-eluting stents (PES) and sirolimus-eluting stent (SES) in neointimal proliferation under strictly matched conditions remain to be clarified by optical coherence tomography (OCT). Methods and Results: Between May and December 2007, 27 patients were implanted with a PES and a SES, randomized to either the proximal or distal site in a single coronary artery, and underwent follow-up angiography and OCT examination at 6 months. The frequency of vessel wall apposition with neointima was greater for PES than for SES (92.6% vs 85.8%, P<0.01). The median (25th, 75th percentiles) neointimal thickness (NIT) in PES was significantly greater than that in SES (90 μm [25th: 40 μm; 75th: 200 μm] vs 50 μm [25th: 20 μm; 75th: 140 μm]; P<0.01). Both the average difference between the maximum and minimum NIT in each cross-section and the average difference between the maximum and minimum NIT in the longitudinal axis were larger in PES than in SES (206±88 vs 131±57 μm; P<0.001, 607±243 vs 400±185 μm; P<0.001). Low-density spots were significantly more frequently observed in PES than in SES (30.9% vs 17.0%, P=0.001). Conclusions: Compared with SES, PES had a non-uniform and larger neointimal thickness with fewer uncovered struts, and more peri-strut low-density areas. (Circ J 2010; 74: 903 - 908)

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