Chest
Clinical InvestigationsCardiologyRespiratory Muscle Strength and Hemodynamics in Chronic Heart Failure
Section snippets
Patient Population
We studied 23 patients with CHF (18 male and 5 female, mean age ± SD, 59.3 ± 9.2 years) and 15 age-matched healthy volunteers (12 male and 3 female, 60.2 ± 6.2 years). Patients with CHF consisted of seven with old myocardial infarction, eight with old myocardial infarction and angina pectoris, four with mitral valve disease, and four with dilated cardiomyopathy (Table 1). Each patient was examined while in a stable hemodynamic condition and free of acute exacerbation, although all the patients
Results
The anthropometric data are shown in Table 2. Ages were not significantly different among group A, group B, and controls. Height and body weight did not differ significantly among three groups. Plasma albumin level in group A was not significantly lower than that in group B (3.7 ± 0.2 and 3.9 ± 0.3 g/dl, respectively). Six of 13 patients with group A and 2 of 10 patients with group B showed myocardial ischemic response during exercise test.
Mean values of pulmonary function variables showed
Discussion
We have demonstrated that respiratory muscle strength exhibited reduction in patients with severe CHF and that the impairment in inspiratory muscle strength was intimately related to the deterioration in cardiac function and to the impaired exercise capacity. This may support our hypothesis that, if respiratory muscle strength is dependent on the cardiac dysfunction, the patients with CHF should exhibit respiratory muscle weakness related to cardiac output.
Our present study showed that patients
ACKNOWLEDGMENT
The authors thank H. Yamabe, M.D., and A. Hashimoto, M.D., for invaluable help in exercise data collection.
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2022, Progress in Cardiovascular DiseasesCitation Excerpt :To date, most of the research investigating inspiratory muscle weakness in CVD has focused on HF with reduced ejection fraction (HFrEF). Inspiratory muscle weakness is prevalent in patients with HFrEF with ~40% of these patients exhibiting MIP <70% of predicted,15 and patients with HFrEF commonly exhibit lower MIP compared to healthy adults.10,26–29 Importantly, inspiratory muscle weakness is associated with worse long-term outcomes (e.g., mortality) in patients with HFrEF.10,15,30
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2018, Conn's Handbook of Models for Human AgingInspiratory Muscle Function and Exercise Capacity in Patients With Heart Failure With Preserved Ejection Fraction
2017, Journal of Cardiac FailureCitation Excerpt :To our knowledge, this is the first study evaluating the association between pp-MIP and peak VO2 in symptomatic and elderly patients with HFpEF. Previous studies in HFrEF have shown a positive association between MIP and peak VO2.9,15,16 For instance, Nishimura et al15 in 1994 evaluated 23 patients with HFrEF (NYHA class II-III) and concluded that MIP correlated positively with cardiac index and maximal oxygen consumption (r = 0.460 and r = 0.503, P < .05, respectively).
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2011, International Journal of CardiologyCitation Excerpt :However, the present study is the first to investigate the association between respiratory muscle dysfunction and pulmonary hypertension in CHF patients. Previous observations were limited by a smaller number of CHF patients, and the impairment in inspiratory muscle strength was related to the deterioration in the cardiac functional state as indicated by a low cardiac index [9]. This is consistent with the present findings.