Chest
Distensibility of the Ascending Aorta in Coronary Artery Disease and Changes After Nifedipine Administration
Section snippets
Study Population
Eighty-two consecutive male patients, with an age range from 40 to 50 years, who had undergone diagnostic cardiac catheterization for evaluation of chest pain were selected as potential subjects for the study. Patients with arterial hypertension (systolic arterial pressure ≥140 mm Hg and/or diastolic arterial pressure ≥90 mm Hg), valvular heart disease, history of previous myocardial infarction, congenital heart disease, dilated cardiomyopathy, ejection fraction <58 percent (value corresponding
Demographic and Baseline Characteristics
Table 1 shows the demographic and baseline characteristics in normal subjects and patients with coronary artery disease. Age, body surface area, heart rate, and blood pressure, as well as diastolic and systolic aortic diameters, were not statistically different between the two groups. The pulsatile change in aortic diameter, however, was significantly lower in patients with coronary artery disease compared with normal subjects.
Aortic Distensibility: Patients with coronary artery disease had a
DISCUSSION
The present study showed that distensibility of the ascending aorta is decreased in the presence of coronary artery disease and demonstrated that nifedipine administration increased the aortic distensibility in both normal subjects and patients with coronary artery disease. The increase of the aortic distensibility, in absolute values, due to nifedipine administration was significantly less in patients with coronary artery disease compared with normal subjects; however, the percentage change in
ACKNOWLEDGMENT
Special thanks to Helen Simnou for her excellent secretarial support in the preparation of the manuscript.
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This work was supported by a grant from the Hellenic Heart Foundation.
Manuscript received May 27, 1993; revision accepted October 13