Chest
Clinical Investigations: Pulmonary FunctionRole of Respiratory Function in Exercise Limitation in Chronic Heart Failure
Section snippets
Study Design
The study was designed to determine whether added vd increases peak e or decreases exercise capacity during incremental exercise in patients with stable chronic heart failure. Patients performed two maximal incremental exercise tests on a cycle ergometer (Godart; Utrecht, The Netherlands) in random order; one was performed with added vd, and one without added vd. Apart from the added vd, the two tests were identical.
Patients
Patients were considered eligible for the study if they had stable
Results
Seven patients (four men and three women) were studied. Their average age was 55 years, with a range of 37 to 70 years. The mean LVEF of our study population was 0.28, with a range of 0.20 to 0.40. Heart failure was secondary to idiopathic dilated cardiomyopathy in four patients, ischemic cardiomyopathy in two patients, and hypertensive cardiomyopathy in one patient. All patients used an angiotensin-converting enzyme inhibitor, five used digoxin, four used diuretics, two used aspirin, one used
Discussion
We have demonstrated that chronic heart failure patients have significant ventilatory reserve at end exercise and are able to further increase their maximal e, indicating that respiratory function does not contribute to limitation of exercise in chronic heart failure patients.
During control exercise, our chronic heart failure patients demonstrated impaired exercise performance as evident by their low peak o2. The ventilatory response to exercise (ie, e/ co2) was
ACKNOWLEDGMENT
The authors thank Mrs. I. Fairlie for her assistance in preparation of this manuscript.
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Supported by the Saskatchewan Lung Association, and the Heart and Stroke Foundation of Canada. Dr. Marciniuk is a Saskatchewan Lung Association Research Professor.