Chest
A Role for the Carotid Body in Cardiovascular Control in Man
Section snippets
METHODS
Eight patients between 16 and 48 years of age with histories of bronchial asthma, who had undergone bilateral carotid body resection at other institutions two weeks to eight years previously, were the experimental subjects. We included only patients who were asymptomatic and who had essentially normal respiratory function at the time. Histologic documentation of bilateral carotid body resection was obtained on all of these patients. In addition, none developed hyperpnea in response to arterial
RESULTS
As demonstrated previously, the CBR subjects had no ventilatory response to breathing 12 percent O2 in nitrogen, and their ventilatory response to 5 percent CO2 in 21 percent O2 in N2 was reduced in comparison to the control group.19 The subjects who had bilateral carotid body resection, as well as the control subjects, had normal baroreceptor function as demonstrated by a normal blood pressure overshoot and bradycardia following a Valsalva maneuver, a blood pressure decrease and bradycardia
DISCUSSION
It is well established that the carotid bodies have an important role in ventilatory control,1, 2, 9, 21, 22 and that these structures are essential for the normal ventilatory responses to hypoxia and hypercapnia in man.17, 18, 19, 23, 24 In spite of intensive studies in laboratory animals, little is known about the physiologic effects of carotid body denervation, without concomitant loss of carotid sinus function, on ardiovascular phenomena. Jacobs et al11 were able to selectively denervate
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This investigation was supported by USPHS grants HL-11907 and HL-05916.