Chest
Ventilatory and Diffusion Abnormalities in Potential Heart Transplant Recipients
Section snippets
MATERIALS AND METHODS
Three hundred and fifteen patients were evaluated at UCLA Medical Center for potential cardiac transplantation. Criteria for consideration for possible heart transplantation included either intractable congestive heart failure which markedly impaired the quality of life or a very high likelihood of sudden cardiac death within the next year, in the absence of other reasonable surgical options.6 Of this group, 132 patients (105 men and 27 women, mean age 51 years) underwent pulmonary function
RESULTS
Subject characteristics are shown in Table 1. The majority of the patients were middle-aged men who were either former or current smokers. Although a few patients presented with congestive heart failure of only brief duration, most patients had either class 3 or 4 disease according to the New York Heart Association Classification. The etiology of heart disease was coronary artery disease in 54 percent, idiopathic in 21 percent, valvular heart disease in 8 percent, viral cardiomyopathy in 5
DISCUSSION
Diffusion impairment either alone or combined with ventilatory restriction and/or obstruction was found in 67 percent of patients with severe congestive heart failure who underwent pulmonary function testing as part of an evaluation for possible heart transplantation. Isolated diffusion impairment was the single most common abnormality, occurring in 31 percent of these patients. Because significant restriction was not present in the latter patients, the diffusion impairment could not be
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2017, Best Practice and Research: Clinical AnaesthesiologyPulmonary function impairment in patients with chronic heart failure: Lower limit of normal versus conventional cutoff values
2014, Heart and Lung: Journal of Acute and Critical CareCitation Excerpt :This was also true for patients in a stable clinical condition who did not have signs of pulmonary congestion. Prevalence rates of diffusion impairment and airway obstruction were 41–93%13–19 and 14–60%,13–18,20,21 respectively, in prior studies that have often included heart transplant recipients. Our results extend these studies by demonstrating that these abnormalities are also highly prevalent in patients with less severe heart failure who were mainly in NYHA class II.
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Presented in part at the annual meeting, American Thoracic Society, Cincinnati, May 15, 1989.
Manuscript received January 10; revision accepted March 13.