Coronary Arterial Plaque Characterized by Multislice Computed Tomography Predicts Complications Following Coronary Intervention

Yukihiko Kinohira; Yasushi Akutsu; Hui-Ling Li; Yuji Hamazaki; Masayuki Sakurai; Yuka Saiki; Yusuke Kodama; Hideki Nishimura; Hideyuki Yamanaka; Akira Shinozuka; Takehiko Gokan; Takashi Katagiri

doi:10.1536/ihj.48.25

Clinical Studies

Coronary Arterial Plaque Characterized by Multislice Computed Tomography Predicts Complications Following Coronary Intervention

Yukihiko Kinohira, Yasushi Akutsu, Hui-Ling Li, Yuji Hamazaki, Masayuki Sakurai, Yuka Saiki, Yusuke Kodama, Hideki Nishimura, Hideyuki Yamanaka, Akira Shinozuka, Takehiko Gokan, Takashi Katagiri

Author information

Yukihiko Kinohira
Third Department of Internal Medicine (Division of Cardiology), Showa University School of Medicine
Yasushi Akutsu
Third Department of Internal Medicine (Division of Cardiology), Showa University School of Medicine
Division of Nuclear Medicine, Showa University School of Medicine
Hui-Ling Li
Third Department of Internal Medicine (Division of Cardiology), Showa University School of Medicine
Department of Radiology, Showa University School of Medicine
Yuji Hamazaki
Third Department of Internal Medicine (Division of Cardiology), Showa University School of Medicine
Masayuki Sakurai
Third Department of Internal Medicine (Division of Cardiology), Showa University School of Medicine
Yuka Saiki
Third Department of Internal Medicine (Division of Cardiology), Showa University School of Medicine
Yusuke Kodama
Third Department of Internal Medicine (Division of Cardiology), Showa University School of Medicine
Hideki Nishimura
Third Department of Internal Medicine (Division of Cardiology), Showa University School of Medicine
Hideyuki Yamanaka
Third Department of Internal Medicine (Division of Cardiology), Showa University School of Medicine
Akira Shinozuka
Division of Nuclear Medicine, Showa University School of Medicine
Takehiko Gokan
Department of Radiology, Showa University School of Medicine
Takashi Katagiri
Third Department of Internal Medicine (Division of Cardiology), Showa University School of Medicine

Keywords: Multislice computed tomography (MSCT), Percutaneous coronary intervention (PCI), Coronary plaque

JOURNAL FREE ACCESS

2007 Volume 48 Issue 1 Pages 25-33

DOI https://doi.org/10.1536/ihj.48.25

Details

Abstract

Background:
A reliable, noninvasive assessment of plaque configuration would constitute an important step forward for predicting complications following percutaneous coronary intervention (PCI). Multislice computed tomography (MSCT) holds promise with respect to allowing for differentiation of coronary lesion configuration. However, it has not yet been clarified whether the characteristics of coronary artery plaque measured by MSCT predict complications after PCI. The aim of this study was to investigate the relationship between plaque configuration and complications after coronary intervention in patients with stable angina pectoris.
Methods:
MSCT was performed in patients with angina pectoris who were scheduled for PCI prospectively, and 26 patients (70 ± 11 years, 18 males) with coronary artery plaque in a stenotic coronary artery measured by MSCT were recruited for this study. Thirty-five plaques in the stenotic coronary lesions were divided into 3 groups based on the CT density as soft, intermediate, and hard, and were compared with the complications after PCI.
Results:
The soft plaque group before PCI (n = 11) was significantly associated with the appearance of slow flow (n = 4) or a compromised side branch (n = 1) after PCI, whereas the hard plaque group before PCI (n = 17) was associated with the appearance of dissection (n = 2) or perforation (n = 1) after PCI (P = 0.004). The intermediate plaque group (n = 7) had only one complication, a compromised side branch (n = 1).
Conclusion:
Coronary arterial plaque characterized by MSCT can predict intervention-related complication. It may be important for the risk stratification of the patients scheduled to undergo PCI to investigate plaque configuration by MSCT.

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