References
Stokes GS, Shenfield GM, Johnston HJ, et al. Timing of blood pressure measurements in determining anomalies in duration of effect of an antihypertensive drug: assessment of isradipine. J Cardiovasc Pharmacol 1990; 15 Suppl. 1: S65–S69
Rose M, McMahon FG. Some problems with antihypertensive drug studies in the context of the new guidelines. Am J Hypertens 1990; 3: 151–5
Elliott HL, Meredith PA. Defining trough: peak ratios for antihypertensive drugs. J Hypertens. In press
Mutti E, Trazzi S, Omboni S, et al. Effects of placebo on 24 hour non-invasive ambulatory blood pressure. J Hypertens 1991; 9: 361–4
Gerin W, Rosofsky M, Pieper C, et al. A test of reproducibility of blood pressure and heart rate variability using a controlled ambulatory procedure. J Hypertens 1993; 11: 1127–31
White WB. Analysis of ambulatory blood pressure data in an antihypertensive trial. J Hypertens 1991; 9 Suppl. 1: S27–S32
Zannad F. Trandolapril: how does it differ from other angiotensin converting enzyme inhibitors?. Drugs 1993; 46 Suppl. 2: 172–82
Morgan T, Anderson A. Clinical efficacy of Perindopril in hypertension. Clin Exp Pharmacol Physiol 1992; 19 Suppl. 19: 61–5
Meredith PA, Elliott HL. Antihypertensive treatment and trough:peak ratios: general considerations. J Hypertens. In press
Meredith PA, Perloff D, Mancia G, et al. The impact of therapeutic coverage on the outcome of antihypertensive therapy. J Cardiovasc Pharmacol 1994. In press
Parati G, Pomidossi G, Albini F, et al. Relationship of 24 hour blood pressure mean and variability to severity of target organ damage. J Hypertens 1987; 5: 93–8
Pessina AC, Palatini P, Sperti G, et al. Evaluation of hypertension and related organ damage by average daytime blood pressure. Clin Exp Hypertens 1985; A7: 267–278
Frattola A, Parati G, Cuspidi C, et al. Prognostic value of 24 hour blood pressure variability. J Hypertens 1993; 11: 1133–77
Rudd P. Partial compliance implications for clinical practice. J Cardiovasc Pharmacol 1993; 22 Suppl. A: S1–S5
Detry J-M, Block P, DeBacker G, et al. Patient compliance and therapeutic coverage: amlodipine versus nifedipine slow release in the treatment of hypertension and angina pectoris. Am J Cardiol 1994. In press
Donnelly R, Meredith PA, Miller SHK, et al. Pharmacodynamic modelling of the antihypertensive response to amlodipine. Clin Pharmacol Ther 1993; 54: 303–10
Zanchetti A, Bianchi L, Amigoni S. Antihypertensive effects of nifedipine GITS 30 mg and 60 mg versus placebo on clinic and ambulatory blood pressures in essential hypertensives. J Hypertens 1993; 11 Suppl. 5: S334–S335
Ueda S, Meredith PA, Howie CA, et al. A comparative assessment of the duration of action of amlodipine and nifedipine GITS in normotensive subjects. Br J Clin Pharmac 1993; 36: 561–6
Vaur L, Dutrey-Dupagne C, Genes N, et al. Differential effects of a missed dose of trandolapril and enalapril on the blood pressure control of hypertensives. Am J Hypertens. In press
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Meredith, P.A. Trough/Peak Ratios for Antihypertensive Agents. Drugs 48, 661–666 (1994). https://doi.org/10.2165/00003495-199448050-00001
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DOI: https://doi.org/10.2165/00003495-199448050-00001