Abstract
A prospective, randomized, double-blind study to compare the efficacy in terminating postoperative atrial fibrillation of the class Ic drug propafenone versus class Ia drug procainamide was conducted. Intravenous propafenone was superior to procainamide in achieving rapid cardioversion and a better rate control with a lower incidence of symptomatic hypotension.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Anti-Arrhythmia Agents / adverse effects
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Anti-Arrhythmia Agents / therapeutic use*
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Atrial Fibrillation / drug therapy*
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Atrial Fibrillation / etiology
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Atrial Fibrillation / physiopathology
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Cardiac Surgical Procedures / adverse effects*
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Coronary Artery Bypass / adverse effects
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Double-Blind Method
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Drug Administration Schedule
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Electrocardiography, Ambulatory
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Female
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Heart Rate / drug effects*
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Heart Valves / surgery
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Humans
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Hypotension / chemically induced
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Infusions, Intravenous
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Male
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Middle Aged
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Procainamide / adverse effects
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Procainamide / therapeutic use*
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Propafenone / adverse effects
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Propafenone / therapeutic use*
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Treatment Outcome
Substances
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Anti-Arrhythmia Agents
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Propafenone
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Procainamide