Abstract
We examined the impact of serum cholesterol and cigarette smoking on the coronary vasomotor effects of L-arginine in patients with atherosclerotic coronary artery disease. The dilation of proximal and distal segments in response to low-dose L-arginine was greater in patients with a serum cholesterol level < or =200 mg/dl than in patients with a level >200 mg/dl, whereas the response was the same in smokers and nonsmokers.
MeSH terms
-
Arginine* / administration & dosage
-
Biomarkers / blood
-
Cholesterol / blood*
-
Coronary Angiography
-
Coronary Artery Disease / blood*
-
Coronary Artery Disease / diagnosis
-
Coronary Artery Disease / etiology
-
Coronary Vessels / drug effects
-
Coronary Vessels / physiopathology*
-
Exercise Test
-
Female
-
Humans
-
Hypercholesterolemia / blood
-
Hypercholesterolemia / complications
-
Injections, Intra-Arterial
-
Male
-
Middle Aged
-
Nitroglycerin / administration & dosage
-
Prognosis
-
Smoking / adverse effects*
-
Vasodilation / drug effects*
-
Vasodilator Agents / administration & dosage
Substances
-
Biomarkers
-
Vasodilator Agents
-
Arginine
-
Cholesterol
-
Nitroglycerin