Serum cholesterol level, cigarette smoking, and vasomotor responses to L-arginine in narrowed epicardial coronary arteries

Am J Cardiol. 2000 Feb 15;85(4):500-3, A11. doi: 10.1016/s0002-9149(99)00781-x.

Abstract

We examined the impact of serum cholesterol and cigarette smoking on the coronary vasomotor effects of L-arginine in patients with atherosclerotic coronary artery disease. The dilation of proximal and distal segments in response to low-dose L-arginine was greater in patients with a serum cholesterol level < or =200 mg/dl than in patients with a level >200 mg/dl, whereas the response was the same in smokers and nonsmokers.

Publication types

  • Comparative Study

MeSH terms

  • Arginine* / administration & dosage
  • Biomarkers / blood
  • Cholesterol / blood*
  • Coronary Angiography
  • Coronary Artery Disease / blood*
  • Coronary Artery Disease / diagnosis
  • Coronary Artery Disease / etiology
  • Coronary Vessels / drug effects
  • Coronary Vessels / physiopathology*
  • Exercise Test
  • Female
  • Humans
  • Hypercholesterolemia / blood
  • Hypercholesterolemia / complications
  • Injections, Intra-Arterial
  • Male
  • Middle Aged
  • Nitroglycerin / administration & dosage
  • Prognosis
  • Smoking / adverse effects*
  • Vasodilation / drug effects*
  • Vasodilator Agents / administration & dosage

Substances

  • Biomarkers
  • Vasodilator Agents
  • Arginine
  • Cholesterol
  • Nitroglycerin