Exclusion of thrombi in the setting of atrial fibrillation (AF) has important implications for early cardioversion. Cardioversion guided by transesophageal echocardiography (TEE) is a safe and relatively cost-effective technique with a high accuracy for detecting left-atrial thrombi. Nowadays, TEE-guided cardioversion may help to select patients suitable for early cardioversion. However, the long-term effect of early TEE-guided cardioversion on the maintenance of sinus rhythm needs to be determined.