Abstract
The present study investigates whether preintervention thrombectomy with a PercuSurge distal balloon protection device can improve final angiographic results compared with adjunctive tirofiban therapy during primary percutaneous coronary intervention (PCI) in large infarct-related arteries (IRAs) (vessel size >/=3.5 mm) with high-burden thrombus formation (HBTF). Results indicate that this mechanical device is superior to adjunctive tirofiban therapy during primary PCI in large IRAs with HBTF in terms of final epicardial flow, microvasculature integrity, and 30-day clinical outcomes.
MeSH terms
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Angioplasty, Balloon, Coronary
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Chi-Square Distribution
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Coronary Angiography
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Coronary Circulation / physiology
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Coronary Thrombosis / diagnostic imaging
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Coronary Thrombosis / drug therapy
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Coronary Thrombosis / therapy*
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Female
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Fibrinolytic Agents / administration & dosage
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Humans
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Male
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Microcirculation / physiology
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Middle Aged
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Myocardial Infarction / diagnostic imaging
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Myocardial Infarction / drug therapy
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Myocardial Infarction / therapy*
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Statistics, Nonparametric
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Thrombectomy / instrumentation*
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Tirofiban
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Treatment Outcome
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Tyrosine / administration & dosage
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Tyrosine / analogs & derivatives*
Substances
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Fibrinolytic Agents
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Tyrosine
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Tirofiban