Multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT): design and clinical protocol

Arthur J Moss; Mary W Brown; David S Cannom; James P Daubert; Mark Estes; Elyse Foster; Henry M Greenberg; W Jackson Hall; Steven L Higgins; Helmut Klein; Mark Pfeffer; David Wilber; Wojciech Zareba

doi:10.1111/j.1542-474X.2005.00073.x

Multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT): design and clinical protocol

Ann Noninvasive Electrocardiol. 2005 Oct;10(4 Suppl):34-43. doi: 10.1111/j.1542-474X.2005.00073.x.

Authors

Arthur J Moss¹, Mary W Brown, David S Cannom, James P Daubert, Mark Estes, Elyse Foster, Henry M Greenberg, W Jackson Hall, Steven L Higgins, Helmut Klein, Mark Pfeffer, David Wilber, Wojciech Zareba

Affiliation

¹ Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA. heartajm@heart.rochester.edu

Abstract

The planned MADIT-CRT trial is designed to determine if CRT-D will reduce the risk of mortality and HF events by approximately 25% in subjects with ischemic (NYHA class I-II) and non-ischemic (NYHA class II) cardiomyopathy, left ventricular dysfunction (EF<or=0.30), and prolonged intraventricular conduction (QRS duration>or=130 ms).

Publication types

Multicenter Study
Randomized Controlled Trial

MeSH terms

Adult
Aged
Aged, 80 and over
Cardiac Pacing, Artificial / statistics & numerical data*
Comorbidity
Defibrillators, Implantable / statistics & numerical data*
Female
Humans
Long QT Syndrome / epidemiology
Long QT Syndrome / therapy*
Male
Middle Aged
Myocardial Ischemia / epidemiology
Myocardial Ischemia / therapy*
Prognosis
Randomized Controlled Trials as Topic
Research Design
Risk Assessment / methods
Risk Factors
Treatment Outcome
United States / epidemiology
Ventricular Dysfunction, Left / epidemiology
Ventricular Dysfunction, Left / therapy*