Lack of evidence for involvement of Epstein-Barr virus in the development of the "Quilty" lesion of transplanted hearts: an in situ hybridization study

R E Nakhleh; C M Copenhaver; K Werdin; K McDonald; S H Kubo; J G Strickler

Lack of evidence for involvement of Epstein-Barr virus in the development of the "Quilty" lesion of transplanted hearts: an in situ hybridization study

J Heart Lung Transplant. 1991 Jul-Aug;10(4):504-7.

Authors

R E Nakhleh¹, C M Copenhaver, K Werdin, K McDonald, S H Kubo, J G Strickler

Affiliation

¹ Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis 55455.

PMID: 1655026

Abstract

We investigated the possible relationship of Epstein-Barr virus to the development of subendocardial lymphocytic infiltrates. In situ hybridization for Epstein-Barr virus genomic sequences was performed in 22 heart biopsy specimens with subendocardial infiltrates for 19 heart transplant patients. Epstein-Barr virus genomic sequences were not detected in the lymphocytes or myocytes in any of the heart biopsy specimens. We conclude that Epstein-Barr virus is not related to the development of subendocardial lymphocytic infiltrates.

MeSH terms

Biopsy
DNA Probes
DNA, Viral / analysis*
Female
Genome, Viral*
Heart Transplantation / pathology*
Herpesvirus 4, Human / genetics
Herpesvirus 4, Human / isolation & purification*
Humans
Lymphocytes / microbiology*
Lymphocytes / pathology
Male
Middle Aged
Myocardium / pathology*

Substances

DNA Probes
DNA, Viral