A hallmark of noninvasive testing has been the identification of patients with coronary artery disease. Now, with multislice computed tomography (MSCT), information about coronary anatomy can be obtained without the need for catheterization. A major concern with the application of MSCT coronary angiography is the radiation exposure to the patient. Both MSCT and selective coronary angiography share the risks of procedure-related complications, such as allergic contrast reactions, and stochastic risks (i.e., cancer induction) of low-level radiation. There is a substantially higher radiation dose for MSCT angiography (effective dose [ED] 14 mSv) than for CCA (ED 6 mSv). These exposures yield lifetimes risks of 0.07% and 0.02%, respectively, of inducing a fatal cancer in the general (i.e., age- and gender-averaged) population. However, CCA poses additional serious risks associated with cardiac catheterization, yielding a non-radiogenic risk of mortality--excluding contrast reactions--of 0.11%. Combining the radiogenic and non-radiogenic risks (0.02% and 0.11%, respectively) yields a 0.13% overall risk of mortality from CCA--nearly two-fold higher than that for MSCT angiography (0.07%). If one were to use the lower, more age-appropriate risk factors for the older patient population in question, the radiogenic risks of both CCA and MSCT would be reduced by about one-half, further widening the overall safety ratio of MSCT relative to CCA. When weighing the relative risks of alternative medical procedures, therefore, it is imperative that one consider the overall risk of the respective procedures.