Abstract
Telomeres are nucleoprotein structures that shelter the ends of linear chromosomes from being inappropriately recognized as DNA double-strand breaks. New work has revealed that Apollo, a nuclease previously implicated in DNA repair, also has a role in safeguarding telomeres during S phase.
MeSH terms
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DNA Repair
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DNA Repair Enzymes
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Exodeoxyribonucleases / genetics
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Exodeoxyribonucleases / metabolism
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Exodeoxyribonucleases / physiology*
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Gene Expression Regulation
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Humans
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism
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Nuclear Proteins / physiology*
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Protein Subunits / metabolism
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S Phase
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Shelterin Complex
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TATA Box Binding Protein-Like Proteins / metabolism
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Telomere / metabolism*
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Telomere-Binding Proteins / metabolism
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Telomeric Repeat Binding Protein 2
Substances
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Nuclear Proteins
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Protein Subunits
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Shelterin Complex
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TATA Box Binding Protein-Like Proteins
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TERF2 protein, human
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Telomere-Binding Proteins
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Telomeric Repeat Binding Protein 2
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DCLRE1B protein, human
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Exodeoxyribonucleases
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DNA Repair Enzymes