Molecular events underlying pregnancy-induced cardiomyopathy

Leslie A Leinwand

doi:10.1016/j.cell.2007.01.020

Molecular events underlying pregnancy-induced cardiomyopathy

Cell. 2007 Feb 9;128(3):437-8. doi: 10.1016/j.cell.2007.01.020.

Author

Leslie A Leinwand¹

Affiliation

¹ Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA. leinwand@colorado.edu

PMID: 17289564
DOI: 10.1016/j.cell.2007.01.020

Abstract

The etiology of cardiomyopathy in pregnant women remains unclear. In this issue, Hilfiker-Kleiner et al. (2007) report that a reduction in STAT3 and a concomitant increase in cathepsin D may be a cause of this disease. Cathepsin D generates an antiangiogenic cleavage product of the hormone prolactin. The authors show that an inhibitor of prolactin secretion may be useful in treating this disease.

Publication types

Comment

MeSH terms

Animals
Bromocriptine / therapeutic use
Cardiomyopathies / drug therapy
Cardiomyopathies / metabolism*
Cathepsin D / metabolism*
Disease Models, Animal
Female
Humans
Pregnancy
Pregnancy Complications, Cardiovascular / metabolism*
Prolactin / antagonists & inhibitors
Prolactin / metabolism*
Puerperal Disorders / drug therapy
Puerperal Disorders / metabolism*
STAT3 Transcription Factor / metabolism*

Substances

STAT3 Transcription Factor
Bromocriptine
Prolactin
Cathepsin D