Therapeutic combination of sildenafil and iloprost in a preterm neonate with pulmonary hypertension

Berkan Gürakan; Petek Kayiran; Nilüfer Oztürk; Sinan Mahir Kayiran; Aygün Dindar

doi:10.1002/ppul.21415

Therapeutic combination of sildenafil and iloprost in a preterm neonate with pulmonary hypertension

Pediatr Pulmonol. 2011 Jun;46(6):617-20. doi: 10.1002/ppul.21415. Epub 2011 Mar 24.

Authors

Berkan Gürakan¹, Petek Kayiran, Nilüfer Oztürk, Sinan Mahir Kayiran, Aygün Dindar

Affiliation

¹ Division of Neonatology, Department of Pediatrics, American Hospital, Istanbul, Turkey.

PMID: 21438177
DOI: 10.1002/ppul.21415

Abstract

While new pharmacological approaches have been demonstrated to effectively manage PH in adults, few reports have addressed PH treatment in neonates and infants. This case report describes the successful management of severe PH secondary to bronchopulmonary dysplasia, respiratory syncytial virus infection, and hypoxia in a preterm 4-month-old with the long-term use of orally administered sildenafil and inhaled iloprost.

Publication types

Case Reports

MeSH terms

Administration, Inhalation
Administration, Oral
Bronchopulmonary Dysplasia / complications
Drug Therapy, Combination
Humans
Hypertension, Pulmonary / drug therapy*
Hypertension, Pulmonary / etiology
Hypertension, Pulmonary / physiopathology
Hypoxia / complications
Iloprost / administration & dosage
Iloprost / therapeutic use*
Infant
Infant, Newborn
Infant, Premature
Male
Piperazines / administration & dosage
Piperazines / therapeutic use*
Purines / administration & dosage
Purines / therapeutic use
Respiratory Syncytial Virus Infections / complications
Sildenafil Citrate
Sulfones / administration & dosage
Sulfones / therapeutic use*
Treatment Outcome
Vasodilator Agents / administration & dosage
Vasodilator Agents / therapeutic use*

Substances

Piperazines
Purines
Sulfones
Vasodilator Agents
Sildenafil Citrate
Iloprost