A literature review has addressed the two major factors in disease progression in sick sinus syndrome: atrioventricular block and atrial fibrillation. An incidence of atrioventricular block of 8.4 percent in a follow-up period of 34.2 months is considered clinically significant and sufficient to justify use of a ventricular lead in pacemaker management. Atrial fibrillation occurs much more commonly (22.3%) in ventricular pacing than with atrial demand pacing (3.9%) in a 2 1/2 year observation period. Coincident with the reduction in arrhythmia achieved by atrial demand pacing is a significant reduction in systemic embolism (1.6% vs. 13%). This is considered largely to be due to the improved rhythm control with AAI pacing but also possibly to the avoidance of retrograde atrioventricular conduction. The benefits of AAI pacing in terms of mortality in sick sinus syndrome have not yet been fully assessed. In the future, DDI pacing is recommended with, in some patients, the addition of another sensor to provide rate responsiveness on exercise.