Fenoldopam for the prevention of contrast-induced nephropathy (CIN)-do we need more trials? A meta-analysis

Clin Imaging. 2015 Sep-Oct;39(5):759-64. doi: 10.1016/j.clinimag.2015.02.003. Epub 2015 Feb 12.

Abstract

We conducted a pooled analysis of clinical trials comparing intravenous Fenoldopam (FP) with Saline/Placebo/N-acetyl cysteine (NAC) for the prevention of contrast-induced nephropathy (CIN). Five studies were eligible. Quantitative analyses were done with Review Manager (RevMan version 5.2.). A total of 85 out of 353 patients in Fenoldopam group while 73 among 366 in the control group were affected due to CIN. The risk ratio for the development of CIN in the Fenoldopam group was 1.19 compared to the control group. This was not statistically significant. Fenoldopam is no better than Placebo/Saline or NAC in preventing CIN, but more studies are required.

Keywords: Contrast nephropathy; Corlopam; Fenoldopam; N-acetylcysteine.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Contrast Media / adverse effects*
  • Dopamine Agonists / therapeutic use*
  • Fenoldopam / therapeutic use*
  • Humans
  • Kidney Diseases / chemically induced*
  • Kidney Diseases / prevention & control*

Substances

  • Contrast Media
  • Dopamine Agonists
  • Fenoldopam