Aspirin plus ticlopidine prevented experimental endocarditis due to Enterococcus faecalis and Streptococcus gallolyticus

Pathog Dis. 2015 Nov;73(8):ftv060. doi: 10.1093/femspd/ftv060. Epub 2015 Aug 26.

Abstract

Enterococcus faecalis and Streptococcus gallolyticus cause infective endocarditis (IE), which can originate from the continuous release or translocation of low bacterial numbers into the bloodstream. In this context, IE cannot be prevented with antibiotics. We previously demonstrated that aspirin plus ticlopidine protected rats from IE due to S. gordonii and Staphylococcus aureus. Here we showed that aspirin plus ticlopidine significantly reduced vegetation weight and protected 73 and 64% rats (P < 0.005) from IE due to E. faecalis and S. gallolyticus, respectively. These results further support the potential use of aspirin plus ticlopidine for a global prevention of IE in high-risk patients.

Keywords: Enterococcus faecalis; Streptococcus gallolyticus; antiplatelets; experimental endocarditis; prophylaxis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aspirin / administration & dosage*
  • Disease Models, Animal
  • Endocarditis, Bacterial / microbiology
  • Endocarditis, Bacterial / prevention & control*
  • Enterococcus faecalis / growth & development*
  • Female
  • Gram-Positive Bacterial Infections / microbiology
  • Gram-Positive Bacterial Infections / prevention & control*
  • Platelet Aggregation Inhibitors / pharmacology*
  • Rats, Wistar
  • Streptococcus / growth & development*
  • Ticlopidine / administration & dosage*
  • Treatment Outcome

Substances

  • Platelet Aggregation Inhibitors
  • Ticlopidine
  • Aspirin