Each of the 54 criteria in the Selvester 32-point QRS scoring system for estimation of myocardial infarct (MI) size has attained greater than or equal to 95% specificity in normal subjects. This study was performed to identify a subset of those criteria with cumulative specificity greater than or equal to 95% and maximal sensitivity for use in screening for the presence of non-acute MI. Coronary angiography and left ventriculography were used to identify 500 normal subjects, 60 patients with isolated anterior MI and 62 patients with isolated inferior MI. Patients with the QRS confounding factors of ventricular hypertrophy, fascicular block or bundle branch block on their electrocardiogram were not included. Using stepwise logistic regression analysis, the screening criteria identified were: (1) Q greater than or equal to 30 ms in aVF, (2) R less than or equal to 10 ms and less than or equal to 0.1 mV in V2 and (3) R greater than or equal to 40 ms in V1. Cumulatively, these 3 screening criteria achieved 84% and 77% sensitivities for inferior and anterior MI groups, respectively. Thus, a set of 3 criteria from the Selvester QRS scoring system is capable of identifying single non-acute anterior or inferior MI in 80% of patients, and falsely indicating presence of MI in only 5% of normal subjects.