An index for assessing blindness in a multi-centre clinical trial: disulfiram for alcohol cessation--a VA cooperative study

K E James; D A Bloch; K K Lee; H C Kraemer; R K Fuller

doi:10.1002/(SICI)1097-0258(19960715)15:13<1421::AID-SIM266>3.0.CO;2-H

An index for assessing blindness in a multi-centre clinical trial: disulfiram for alcohol cessation--a VA cooperative study

Stat Med. 1996 Jul 15;15(13):1421-34. doi: 10.1002/(SICI)1097-0258(19960715)15:13<1421::AID-SIM266>3.0.CO;2-H.

Authors

K E James¹, D A Bloch, K K Lee, H C Kraemer, R K Fuller

Affiliation

¹ VA Medical Center, Oregon Health Sciences University, Portland 97201, USA.

PMID: 8841652
DOI: 10.1002/(SICI)1097-0258(19960715)15:13<1421::AID-SIM266>3.0.CO;2-H

Abstract

This paper considers an index to assess the success of blinding with application to a clinical trial of disulfiram. The index increases as the success of blinding increases, accounts for uncertain responses, and is scaled to an interval of 0.0 to 1.0, 0.0 being complete lack of blinding and 1.0 being complete blinding.

Publication types

Clinical Trial
Randomized Controlled Trial
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Alcohol Deterrents / therapeutic use
Alcoholism / drug therapy
Bias
Disulfiram / therapeutic use
Double-Blind Method*
Hospitals, Veterans
Humans
Multicenter Studies as Topic / standards*
Randomized Controlled Trials as Topic / standards*
Reproducibility of Results
Research Design / standards*

Substances

Alcohol Deterrents
Disulfiram