Blockade of K(ATP) channels with glibenclamide does not abolish preconditioning during demand ischemia

S D Correa; S Schaefer

doi:10.1016/s0002-9149(96)00681-9

Blockade of K(ATP) channels with glibenclamide does not abolish preconditioning during demand ischemia

Am J Cardiol. 1997 Jan 1;79(1):75-8. doi: 10.1016/s0002-9149(96)00681-9.

Authors

S D Correa¹, S Schaefer

Affiliation

¹ Department of Internal Medicine, University of California, Davis 95616, USA.

PMID: 9024742
DOI: 10.1016/s0002-9149(96)00681-9

Abstract

The role of adenosine triphosphate-sensitive potassium channels in the adaptive response to demand ischemia was tested in 22 patients treated with placebo or glibenclamide before sequential exercise testing or atrial pacing. Glibenclamide did not affect the improvement in signs of ischemia in both protocols, indicating that opening of these channels is not a mechanism of this adaptive response in humans.

Publication types

Clinical Trial
Randomized Controlled Trial

MeSH terms

Adaptation, Physiological
Adenosine Triphosphate / pharmacology
Aged
Cardiac Pacing, Artificial
Double-Blind Method
Electrocardiography
Exercise Test
Female
Glyburide / pharmacology*
Humans
Hypoglycemic Agents / pharmacology*
Male
Middle Aged
Myocardial Ischemia / physiopathology*
Potassium Channels / drug effects
Potassium Channels / physiology*

Substances

Hypoglycemic Agents
Potassium Channels
Adenosine Triphosphate
Glyburide