Apoptosis as a possible cause of wall thinning in end-stage hypertrophic cardiomyopathy

T Ino; K Nishimoto; M Okubo; K Akimoto; K Yabuta; S Kawai; R Okada; N Sueyoshi

doi:10.1016/s0002-9149(97)00066-0

Apoptosis as a possible cause of wall thinning in end-stage hypertrophic cardiomyopathy

Am J Cardiol. 1997 Apr 15;79(8):1137-41. doi: 10.1016/s0002-9149(97)00066-0.

Authors

T Ino¹, K Nishimoto, M Okubo, K Akimoto, K Yabuta, S Kawai, R Okada, N Sueyoshi

Affiliation

¹ Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.

PMID: 9114784
DOI: 10.1016/s0002-9149(97)00066-0

Abstract

A 15-year-old boy with hypertrophic cardiomyopathy died of congestive heart failure with progressive left ventricular wall thinning with poor systolic function. Microscopic examination revealed patchy fibrosis in the ventricular myocardium with wall thinning, and immunohistochemical evaluation of apoptosis showed apoptotic cells and bodies in the destroyed myocytes along the border between the fibrotic area and myofibril.

Publication types

Case Reports

MeSH terms

Adolescent
Apoptosis
Cardiomyopathy, Hypertrophic / complications
Cardiomyopathy, Hypertrophic / pathology*
Cardiomyopathy, Hypertrophic / physiopathology*
Echocardiography
Fatal Outcome
Heart Failure / etiology
Heart Failure / pathology
Heart Failure / physiopathology
Humans
Immunohistochemistry
Male
Ventricular Dysfunction, Left / complications
Ventricular Dysfunction, Left / etiology
Ventricular Dysfunction, Left / pathology
Ventricular Dysfunction, Left / physiopathology