Background: Chronic, severe mitral regurgitation is a common clinical entity that can lead to progressive, irreversible left ventricular dysfunction. New information on the natural history of this condition, coupled with advances in surgical technique, have changed the roles of medical and surgical therapies.
Methods: The current medical and surgical literature regarding chronic mitral regurgitation is critically reviewed.
Results: There is no well-defined role for medical therapy in chronic mitral regurgitation. The goal of the treating physician is therefore to choose the optimal timing for surgical intervention. This process begins with noninvasive quantification of the degree of regurgitation. If severe, a careful search for signs or symptoms of impending left ventricular dysfunction should follow. Recent advances in surgical techniques for mitral valve repair allow for correction of the valvular defect with minimal mortality risk and improved preservation of ventricular function and are an impetus for early operative intervention. Mitral valve repair may also be beneficial in the setting of severe dilated cardiomyopathy.
Conclusions: The development of techniques for mitral valve repair has altered the treatment paradigm for severe mitral regurgitation. Surgical intervention before the onset of left ventricular dysfunction is recommended.