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2011 1
2012 1
2013 1
2016 1
2024 0

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Page 1
A pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: the TARGET study.
Newman WG, Payne K, Tricker K, Roberts SA, Fargher E, Pushpakom S, Alder JE, Sidgwick GP, Payne D, Elliott RA, Heise M, Elles R, Ramsden SC, Andrews J, Houston JB, Qasim F, Shaffer J, Griffiths CE, Ray DW, Bruce I, Ollier WE; TARGET study recruitment team. Newman WG, et al. Among authors: sidgwick gp. Pharmacogenomics. 2011 Jun;12(6):815-26. doi: 10.2217/pgs.11.32. Epub 2011 May 3. Pharmacogenomics. 2011. PMID: 21692613 Clinical Trial.
RESULTS: There was no difference in the primary outcome of stopping azathioprine due to an adverse reaction (ADR, p = 0.59) between the two study arms. ADRs were more common in older patients (p = 0.01). ...
RESULTS: There was no difference in the primary outcome of stopping azathioprine due to an adverse reaction (ADR, p = 0.59) between t …
Functional testing of topical skin formulations using an optimised ex vivo skin organ culture model.
Sidgwick GP, McGeorge D, Bayat A. Sidgwick GP, et al. Arch Dermatol Res. 2016 Jul;308(5):297-308. doi: 10.1007/s00403-016-1645-8. Epub 2016 Apr 16. Arch Dermatol Res. 2016. PMID: 27086034 Free PMC article.

Reduced gene expression of alpha-SMA, fibronectin, mast cell tryptase, mast cell chymase, TGF-beta1, CTGF and PAI-1 was observed after 7 and 10 days compared with treated controls (p < 0.05). Histological analysis indicated a reduction in mast cell tryptase and chymase

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Reduced gene expression of alpha-SMA, fibronectin, mast cell tryptase, mast cell chymase, TGF-beta1, CTGF and PAI-1 was observed after 7 and …
Altered expression of hyaluronan synthase and hyaluronidase mRNA may affect hyaluronic acid distribution in keloid disease compared with normal skin.
Sidgwick GP, Iqbal SA, Bayat A. Sidgwick GP, et al. Exp Dermatol. 2013 May;22(5):377-9. doi: 10.1111/exd.12147. Exp Dermatol. 2013. PMID: 23614752

Hyaluronan synthase and HYAL mRNA expression were significantly increased in NS tissue compared with KD tissue (P < 0.05). Immunohistological analysis of tissue indicated an accumulation of HAS and HYAL protein expression in KD compared with NS due to the thicker epider

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Hyaluronan synthase and HYAL mRNA expression were significantly increased in NS tissue compared with KD tissue (P < 0.05). Immunoh

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Identification of fibrocytes from mesenchymal stem cells in keloid tissue: a potential source of abnormal fibroblasts in keloid scarring.
Iqbal SA, Sidgwick GP, Bayat A. Iqbal SA, et al. Among authors: sidgwick gp. Arch Dermatol Res. 2012 Oct;304(8):665-71. doi: 10.1007/s00403-012-1225-5. Epub 2012 Mar 11. Arch Dermatol Res. 2012. PMID: 22407077

The proportion of keloid-derived cells in serum-free or serum-supplemented cultures expressing these fibrocyte markers was greater than from cultures derived from normal scar tissue (p < 0.05). We found that the proliferation of CD45(+)/Col1(+) keloid cells in vitro was

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The proportion of keloid-derived cells in serum-free or serum-supplemented cultures expressing these fibrocyte markers was greater than from …