User profiles for "author:A Escolano"
Amelia EscolanoAssistant Professor at The Wistar Institute Verified email at wistar.org Cited by 2594 |
Progress toward active or passive HIV-1 vaccination
A Escolano, P Dosenovic… - Journal of Experimental …, 2017 - rupress.org
AIDS is a preventable disease. Nevertheless, according to UNAIDS, 2.1 million individuals
were infected with HIV-1 in 2015 worldwide. An effective vaccine is highly desirable. Most …
were infected with HIV-1 in 2015 worldwide. An effective vaccine is highly desirable. Most …
[PDF][PDF] HIV vaccine design to target germline precursors of glycan-dependent broadly neutralizing antibodies
Broadly neutralizing antibodies (bnAbs) against the N332 supersite of the HIV envelope
(Env) trimer are the most common bnAbs induced during infection, making them promising …
(Env) trimer are the most common bnAbs induced during infection, making them promising …
[PDF][PDF] Sequential immunization elicits broadly neutralizing anti-HIV-1 antibodies in Ig knockin mice
A vaccine that elicits broadly neutralizing antibodies (bNAbs) against HIV-1 is likely to be
protective, but this has not been achieved. To explore immunization regimens that might …
protective, but this has not been achieved. To explore immunization regimens that might …
[PDF][PDF] Immunization for HIV-1 broadly neutralizing antibodies in human Ig knockin mice
A subset of individuals infected with HIV-1 develops broadly neutralizing antibodies (bNAbs)
that can prevent infection, but it has not yet been possible to elicit these antibodies by …
that can prevent infection, but it has not yet been possible to elicit these antibodies by …
[PDF][PDF] Antibody affinity shapes the choice between memory and germinal center B cell fates
C Viant, GHJ Weymar, A Escolano, S Chen… - Cell, 2020 - cell.com
Immunological memory is required for protection against repeated infections and is the basis
of all effective vaccines. Antibodies produced by memory B cells play an essential role in …
of all effective vaccines. Antibodies produced by memory B cells play an essential role in …
The microanatomic segregation of selection by apoptosis in the germinal center
INTRODUCTION Germinal centers (GCs) are transient microanatomic structures that form in
lymphoid organs during an immune response. They are the sites of B cell clonal expansion …
lymphoid organs during an immune response. They are the sites of B cell clonal expansion …
Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium
…, J Loschko, RA Karssemeijer, A Escolano… - Journal of Experimental …, 2013 - rupress.org
Dendritic cells (DCs), monocytes, and macrophages are closely related phagocytes that
share many phenotypic features and, in some cases, a common developmental origin …
share many phenotypic features and, in some cases, a common developmental origin …
[HTML][HTML] Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo
M Medina-Ramírez, F Garces, A Escolano… - Journal of Experimental …, 2017 - rupress.org
Induction of broadly neutralizing antibodies (bNAbs) by HIV-1 envelope glycoprotein
immunogens would be a major advance toward an effective vaccine. A critical step in this …
immunogens would be a major advance toward an effective vaccine. A critical step in this …
[HTML][HTML] Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques
Broadly neutralizing monoclonal antibodies protect against infection with HIV-1 in animal
models, suggesting that a vaccine that elicits these antibodies would be protective in …
models, suggesting that a vaccine that elicits these antibodies would be protective in …
[HTML][HTML] Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope
Broadly neutralizing antibodies (bNAbs) isolated from HIV-1-infected individuals inform HIV-
1 vaccine design efforts. Developing bNAbs with increased efficacy requires understanding …
1 vaccine design efforts. Developing bNAbs with increased efficacy requires understanding …